Causes of Thyrotoxicosis 二、甲状腺性甲亢(Thyroidal hyperthyroidism) 1.弥漫性毒性甲状腺肿(Toxic diffuse goiter,.Graves disease,Basedow disease) 2. 多结节性毒性甲状腺肿(toxic multinodular goiter) 3. 甲状腺自主高功能腺瘤(Plummer disease,toxic adenoma) 4. 碘致甲状腺功能亢进症（Iodine hyperthyroidism) 5. 桥本甲亢(Hashitoxicosis) 6. 新生儿甲亢(neonatal hyperthyroidism) 7.垂体性甲亢(Pituitary hyperthyroidism)
Causes of Thyrotoxicosis vqRv#Thyroidal hyperthyroidism NnRbRvqToxic diffuse goiter, Graves disease, Basedow disease ERbRvq(toxic multinodular goiter) vq ·4{Plummer disease, toxic adenoma vq4#®z Iodine hyperthyroidism a_v#(Hashitoxicosis) Zu+v#(neonatal hyperthyroidism) A)Rv# (Pituitary hyperthyroidism
Epidemiology of Hyperthyroidism流行病学 季染来 Females:Males=4 1 女：男=4：1 Age(20-40 years old) 年龄 Family tendency e 家族史
60+,30525.>5->6,79/>750+083øŅĔ ,3(2,8E (2,8FE Eđ Family tendency ¤Ø Age (20-40 years old) ®Ů
Graves disease弥漫性毒性甲状腺肿 Pathogenesis It is an autoimmune disease with thyroid hormones secretion increasing. TSH bind to receptor to TRAb(甲状腺受体抗体) stimulate hormones mimic(模拟)TSH, production Autoantibody Pituitary gland bind to the receptor to receptor TSH Negative TSH receptor feedback control Stimulates Stimulates hormone hormone synthesis synthesis Thyroid cell- ●● ●● ● Regulated production of Unregulated overproduction thyroid hormones of thvroid hormones
Graves disease NnRbRvq 908(4(:95033:4,+08,(8,<09/9/>750+/57354,88,*7,905404*7,(804. TSH bind to receptor to stimulate hormones production !(9/5.,4,808 TRAb (ŽĊƆ\Ì\) mimicBíÍC TSH, bind to the receptor
Clinical Manifestations 甲状腺毒症 甲状腺肿 眼征 胫前黏液水肿 Toxic diffuse goiter Ophthalmopathy Pretibial myxedema Thyrotoxicosis
Clinical Manifestations Thyrotoxicosis vqbz vq Toxic diffuse goiter O Ophthalmopathy 3¸ic Pretibial myxedema