不同表型的线虫突变体aCTHE GENETICSOFCAENORHABDITIS ELEGANSS.BRENNERMedicalResearch CouncilLaboratoryofMolecularBiology,HillsRoad,Cambridge,CBa2OH,EnglandManuscriptreceivedDecemnber10,1973Methods are described for the isolntion,complementationand mapping ofPhotofromtheNobelFoundationmutants of Caenorhabditis elegans,asmall free-livingnematode worm.About3oOEMS-inducodmutants affectingbehaviorand morphologyhave been char-archive.acterizedand about onehundred geneshavebecn definedMutationsin 77ofthese.alterthemovementof theanimal.Estimatesof theinduced mutationfreSydneyBrennerquency of both tha visible mutante and X chromosome lethals suggests that,justasinDrosophila,thegeneticunitsinCelegansarelargePrize share:1/3生物材料：线虫
不同表型的线虫突变体 生物材料：线虫
线虫，图片来源sangerac.uk个体发生模式生物：线虫00:00:00hours10μm通体透明体细胞数目恒定秀丽隐杆线虫(Caenorhabditis elegans, C elegans)生命周期短
个体发生模式生物：线虫 通体透明 体细胞数目恒定 生命周期短 秀丽隐杆线虫 （Caenorhabditis elegans，C elegans）
绘制线虫孵化后的发育树PhotofromtheNobelFoundationPhotofromtheNobelFoundationarchive.archive.JohnE.SulstonH.RobertHorvitzPrize share:1/3Prizeshare:1/3
绘制线虫孵化 后的发育树
PPhotofromtheNobelFoundationarchive.JohnE.Sulston完成的线虫细胞谱系Prizeshare:1/3
完成的线虫细胞谱系
Cell lineage(1090cells)OThe nematodeC.elegans(959 cells)O0Programmed cell death (131 cells)"death genesPhotofromtheNobelFoundation细胞凋亡archive.H.RobertHorvitzdead cellliving cellPrize share:1/3the cell lineage (top left) and the programmedcelldeath(below)inC.elegans
the cell lineage (top left) and the programmed cell death (below) in C. elegans. 细胞凋亡