ATP ADP DEPOLYMERIZATION POLYMERIZATION ADP ATP) Figure 16-51 The trapping of ADP in an actin filament
Figure 16-51 The trapping of ADP in an actin filament
B MF assembly and disassembly Characteristics: (I)Within a me, all the actin monomers are oriented in the same direction, so MF has a polarity Mru end Aunm (pointed)end (a) Brief treatment with trypan Hinge Myosin is region molecular motor for +o。 Myosin Light meromyosin actins (b)Further treatment with tryosin uttragment 2 Pus end 025m Plum (barbed) end (c) EM and diagram of SI fragments "decorating" actin s1) crofllaments
B. MF assembly and disassembly ❖Characteristics: (1) Within a MF, all the actin monomers are oriented in the same direction, so MF has a polarity Myosin is molecular motor for actins
(2) In vitro, (Polymerization) both ends of the mf grow, but the plus end faster than the minus Because actin monomers tend to add to a filament's plus end and leave from its minus end----Tread-milling 8900
(2) In vitro, (Polymerization) both ends of the MF grow, but the plus end faster than the minus. Because actin monomers tend to add to a filament’s plus end and leave from its minus end---- “Tread-milling
(3)Dynamic equilibrium between the G-actin and polymeric forms, which is regulated by ATP hydrolysis and G-actin concentration ADPATP actin with actin with bound ADP bound ATP
(3) Dynamic equilibrium between the G-actin and polymeric forms, which is regulated by ATP hydrolysis and G-actin concentration
(4) Dynamic equilibrium is required for the cell functions. Some MFs are temporary and others permanent (B)
(4) Dynamic equilibrium is required for the cell functions. Some MFs are temporary and others permanent