Chapter 13 Cell apoptosis 1. Extracellular cotrol of cell division cell growth, and apoptosis I Mitogens stimulate G1-Cdk and g1/s-Cdk activities
Chapter 13 Cell apoptosis 1. Extracellular cotrol of cell division, cell growth, and apoptosis Mitogens stimulate G1-Cdk and G1/S-Cdk activities
090÷13=959(c8ll PRIZED Horvitz, and Sulston share Physiology or Medicine Nobel (2002) for their discoveries concerning genetic regulation of organ development and programmed cell death
PRIZED Horvitz, and Sulston share Physiology or Medicine Nobel （2002） “for their discoveries concerning genetic regulation of organ development and programmed cell death” 1090 –131= 959(cells)
衰老 机体结构← 细胞增殖 细胞分化 细胞凋亡 细胞信号转导 染色体 (DNA与蛋白质的相互作用)
机体结构 细胞增殖 细胞分化 细胞凋亡 细胞信号转导 染色体 （DNA与蛋白质的相互作用） 衰老
X A Simplified model of (MAP kinas one way that mitogens stimulate cell division CYTOSOL NUCLEUS SCF subunit ouno ncrcgsod increased increased p27 degradation E2F synthesis G Cak activ G./s-cdk act cyclin D-C cyclin E-Cok increased phosphorylation E2F activity ENTHY IN S PHASE
A simplified model of one way that mitogens stimulate cell division