Genera anesthetics Minimum alveolar concentration (MAC): concentration that prevents movement in response to skin incision in 50%of subjects studied at sea level (1 atmosphere) in 100%oxygen
General anesthetics • Minimum alveolar concentration (MAC): concentration that prevents movement in response to skin incision in 50% of subjects studied at sea level (1 atmosphere) in 100% oxygen
Definition Blood:gas partition coefficient: ratio of the amount dissolved in blood to the amount in the same volume of gas in contact with that blood. The more blood-soluble the agent (high blood-gas partition coefficient),the slower the onset of effect and the slower the patient goes to sleep New inhaled anesthetics have low partition coefficient
Blood:gas partition coefficient: ratio of the amount dissolved in blood to the amount in the same volume of gas in contact with that blood. The more blood-soluble the agent (high blood-gas partition coefficient), the slower the onset of effect and the slower the patient goes to sleep New inhaled anesthetics have low partition coefficient Definition
General anesthetics Example:the time needed for alveolar concentration of the anesthetics reaching 50%of inhaled air isoflurane 210±21s sevoflurane 32士6.7s
General anesthetics Example: the time needed for alveolar concentration of the anesthetics reaching 50% of inhaled air isoflurane 210 ±21 s sevoflurane 32 ±6.7 s
8 0 anesthetic workstation 月000200
anesthetic workstation
Mechanism of inhaled anesthetics ·To be demonstrated
Mechanism of inhaled anesthetics • To be demonstrated