Systemic Autoimmune Diseases Systemic lupus Erythematosus (SLE >Rheumatoid arthritIs(RA) Sⅰ ogren' s syndrome Scleroderma >Dermatomyositis >Mixed connective tissue disease( MCTD)
11 ➢Sjögren’s syndrome ➢Scleroderma ➢Dermatomyositis ➢Mixed connective tissue disease (MCTD) ……. ➢Systemic lupus Erythematosus (SLE) ➢Rheumatoid arthritis (RA) Systemic Autoimmune Diseases
Induction theories for autoimmune Disorders
12 Induction Theories for Autoimmune Disorders
1. Ag released from hidden location(by injury or infection Intraocular antigens Post-traumatic uveitis Sperm Orchitis after vasectomy
13 1. Ag released from hidden location (by injury or infection) Intraocular antigens Post-traumatic uveitis Sperm Orchitis after vasectomy
2. Molecular mimicry( Cross-reactions)
14 2. Molecular mimicry (Cross-reactions)
Molecular mimicry Definition Determinants of infectious agent mimic a host antigen and trigger self-reactive T-cell clones to attack host tissues Examples Rheumatic fever due to group a streptococcus SlE due to Epstein-Barr virus cross reactive with nuclear Sm antigen -yme arthritis due to borrelia burgdorferi reactive With LFA-1(lymphocyte function antigen-1)
15 ➢ Definition: Determinants of infectious agent mimic a host antigen and trigger self-reactive T-cell clones to attack host tissues. ➢ Examples: ➢ Rheumatic fever due to group A streptococcus ➢ SLE due to Epstein-Barr virus cross reactive with nuclear Sm antigen ➢ Lyme artrhritis due to Borrelia burgdorferi reactive with LFA-1 (lymphocyte function antigen-1) Molecular mimicry