Definition of autoimmune disease Disease caused by failure of self-tolerance and subsequent Immune responses against self antigens are called autoimmune diseases
6 Definition of autoimmune disease ➢Disease caused by failure of self-tolerance and subsequent immune responses against self antigens are called autoimmune diseases
>5 to 7 adult affected >Two third women More than 40 human diseases autoimmune in origin
7 ➢5 % to 7% adult affected. ➢Two third women. ➢ More than 40 human diseases autoimmune in origin
Two types of autoimmune disease organ-specific non-organ-specific brain multiple sclerosis(?) thyroid Hashimoto·s thyroiditis primary myxoedema thyrotoxicosis muscle dermatomyositis stomach pernicious anaemia kidney SLE adrenal Addison's disease skin scleroderma pancreas SLE insulin-dependent diabetes mellitus Joints rheumatoid arthritis
8
Organ-Specific Autoimmune Diseases >Insulin-dependent diabetes mellitus > Multiple sclerosis >Myasthenia gravis >Graves's disease >Hashimoto disease > Goodpasture's syndrome
9 ➢Insulin-dependent diabetes mellitus ➢Multiple sclerosis ➢Graves’s disease ➢Myasthenia gravis ➢Hashimoto’ disease ➢Goodpasture’s syndrome …… Organ-Specific Autoimmune Diseases
Systemic autoimmune Diseases
10 Systemic Autoimmune Diseases