The Structure of antibodiesVHNH2HzN3VariableH2NIH①regions5HOOCOCConstant?regionsHOOCCOOHImmunoglobulin4V,domainhttps://en.wikipedia.org/wiki/Antibody#/media/File:lmmunoglobulin_basic_unit.svgFIGURE28.36Thecharacteristic“collapsed b-barrel domain"known as the immunoglobulin fold.CLTLS,TsinghuaUniversitBiochemistry6thbyReginaldH.Garrett,CharlesM.Grisham,2017CengageLearning
The Structure of antibodies https://en.wikipedia.org/wiki/Antibody#/media/File:Immunoglobulin_basic_unit.svg FIGURE 28.36 The characteristic “collapsed b‐barrel domain” known as the immunoglobulin fold. Biochemistry 6th by Reginald H. Garrett, Charles M. Grisham，2017 Cengage Learning Variable regions VH VL Constant regions CLTLS, Tsinghua University
The Structure of antibodies Fab.(Fragment-antigen binding): The part of anantibody molecule which contains the antigen-binding site, consisting of a light chain and part of theheavy chain; it is produced by enzymatic digestion.(papain, pepsin)Fc.(Fragment crystallisable):The portion of anantibody that is responsible for binding to antibodyreceptors on cells and the C1q component ofcomplement.CLTLS,TsinghuaUniversit
The Structure of antibodies • Fab.(Fragment-antigen binding): The part of an antibody molecule which contains the antigenbinding site, consisting of a light chain and part of the heavy chain; it is produced by enzymatic digestion. (papain, pepsin) • Fc.(Fragment crystallisable): The portion of an antibody that is responsible for binding to antibody receptors on cells and the C1q component of complement. CLTLS, Tsinghua University
Antigen-bindingsitesAntigenAntibodyAntigen-antibodycomplexFigure5-22LehningerPrinciplesofBiochemistry.SeventhEdition 2017 W. H. Freeman and CompanyCLTLS,TsinghuaUniversit
CLTLS, Tsinghua University
AntigensAntigenAntigen-bindingsiteAntibodyCLTLS,TsinghuaUniversithttps://commons.wikimedia.org/wiki/File:Antibody.svg
https://commons.wikimedia.org/wiki/File:Antibody.svg CLTLS, Tsinghua University
ACDRSAntigenAntigenVHVLAntigenCH1CLComplementaritydetermining（CDRs）互补决定区regionsFIGURE5-6BindingofanantigenbyanantibodyCLTLS,TsinghuaUniversitCellularandMolecularImmunology7thCopyright2012bySaunders,an imprintof ElsevierInc
FIGURE 5–6 Binding of an antigen by an antibody. Cellular and Molecular Immunology 7th Copyright © 2012 by Saunders, an imprint of Elsevier Inc. Complementarity determining regions (CDRs) 互补决定区 CLTLS, Tsinghua University