Application in Olefin Isostere Design Me H
WuXiͲ Genentech MedChem Team 16 Application in Olefin Isostere Design
Application in Olefin Isostere Design 1992 IMe
WuXiͲ Genentech MedChem Team 17 Application in Olefin Isostere Design 1992
Orexin 1/2 receptor antagonist Orexin 1/2 receptor antagonist CHo N Ki 96
WuXiͲ Genentech MedChem Team 18 Orexin 1/2 receptor antagonist N O N F H O N N N CH3 Ki 96 nM Orexin 1/2 receptor antagonist N O N F O N N N CH3 CH3
Orexin 1/2 receptor antagonist axial methyl >1.2-trans diaxial owest energy conformation
WuXiͲ Genentech MedChem Team 19 Orexin 1/2 receptor antagonist ¾ axial methyl ¾ 1,2Ͳtrans diaxial CH3 Lowest energy conformation
Orexin 1/2 receptor antagonist axial methyl >1.2-trans daxia pl-pl stacking Ushape molecule owest energy conformation
WuXiͲ Genentech MedChem Team 20 Orexin 1/2 receptor antagonist ¾ axial methyl ¾ 1,2Ͳtrans diaxial ¾ piͲpi stacking ¾ U shape molecule CH3 Lowest energy conformation