Primary afferent neurons of the gut (消化道初级感觉神经元) Function: Monitoring and control of the digestive system, including generating appropriate reflex response to the gut lumen contents Participates in reflexes between organs s Convey signals from digestive organs to the CNS Trigger reflex Co-ordination with other body system Relate to sensation including discomfort, nausea, pain and satiety
1 Primary afferent neurons of the gut （消化道初级感觉神经元） Function: Monitoring and control of the digestive system, including: ❖ Generating appropriate reflex response to the gut lumen contents ❖ Participates in reflexes between organs ❖ Convey signals from digestive organs to the CNS – ➢ Trigger reflex ➢ Co-ordination with other body system ➢ Relate to sensation including discomfort, nausea, pain and satiety
Primary afferent neuronS: Extrinsic primary afferent intrinsic and extrinsic neurons, including 内源性和外源性 Vagal primary afferent neuron Stem Have cell bodies in(nodose and gular) ganglia神经节 vagal Primary AFferent Neuron nal com >Spinal primary afferent neuron Immune and Tissue Defence Sanas Intestnofuga Neuron Local and Systemie spinal Primary v have cell bodies in dorsal root Afferent Neuron Endocine Hormones Local and Circulating ganglia ☆ Intestinofugal neuron肠离心神 Intrinsic Pfimary Ameren Neurons Parts of the afferent limbs of Luminal stimulants Buk artoens nutrents entero-enteric reflex pathways talants emmert secretions Have cell bodies in en
2 intrinsic and extrinsic 内源性和外源性 Primary afferent neurons：❖Extrinsic primary afferent neurons, including: ➢Vagal primary afferent neuron ✓have cell bodies in (nodose and jugular) ganglia 神经节 ➢Spinal primary afferent neuron ✓ have cell bodies in dorsal root ganglia ❖Intestinofugal neuron 肠离心神 经元 ➢Parts of the afferent limbs of entero-enteric reflex pathways ➢Have cell bodies in ENS
Intrinsic primary afferent neurons IPANs, within ENS Spinal Cord > Myenteric肌间PANs: respond V Distortion of their processes in the external muscle layers Intrinsic Prmary Afferent Neurons AMeren Neurons v changes in luminal chemistry, via MP processes in the mucosa, Mucosal Chemical Intestinouga Mechano- sCeNE senstve cM> submucosal粘膜下 PANS Neuro detect SM Mechanical distortion of the mucosa Luminal chemistry LM, longitudinal muscle; CM, circular muscle; MP, myenteric plexus; SM submucosa; Muc, mucosa. Nerve endings in the mucosa can be activated by hormones released from entero-endocrine cells(arrows)
3 ❖Intrinsic primary afferent neurons, IPANs, within ENS ➢Myenteric 肌间 IPANs: respond to ✓Distortion of their processes in the external muscle layers ✓changes in luminal chemistry, via processes in the mucosa, ➢submucosal 粘膜下 IPANs detect: ✓Mechanical distortion of the mucosa ✓Luminal chemistry. LM, longitudinal muscle; CM, circular muscle; MP, myenteric plexus; SM, submucosa; Muc, mucosa. Nerve endings in the mucosa can be activated by hormones released from entero-endocrine cells (arrows)
I Intrinsic Primary Afferent Neurons and Nerve circuits within the intestine Reference Furness JB, Jones C,, Nurgali K, Clerc N. Intrinsic primary neurons and nerve circuits within the intestine Progressin Neurobiology 2004, 72: 143-164
4 I Intrinsic Primary Afferent Neurons and Nerve Circuits within the Intestine Reference: Furness JB, Jones C., Nurgali K., Clerc N. Intrinsic primary neurons and nerve circuits within the intestine. Progress in Neurobiology 2004, 72: 143 - 164
1. Types of neurons that form enteric nerve circuits According to the ☆ functions, ☆ key transmitters 9 projections to targets
5 1. Types of neurons that form enteric nerve circuits According to the ❖ functions, ❖ key transmitters ❖ projections to targets