NAL Myenteric neurons 4o 9 10 (1) Ascending interneurons( 5%) (2) Myenteric intrinsic primary fferent neurons(26%) Arte M Gland () Intestinofugal neurons(<1%) (4)Excitatory longitudinal muscle LM: longitudinal muscle: MP: myenteric motor neurons(25%) plexus; CM: circular muscle; SM submucosal plexus: Muc: mucosa 5)Inhibitory longitudinal muscle motor neurons(2% (8)Descending interneurons local reflex(5%) (6) Excitatory circular muscle motor neurons(12%) (9)Descending interneurons(2%) secretomotor reflex (7 Inhibitory circular muscle motor neurons(16%) (10) Descending MMC interneurons(4%)
6 LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa. Myenteric Neurons (1) Ascending interneurons( 5%) (2) Myenteric intrinsic primary afferent neurons (26%) (3) Intestinofugal neurons (<1%) (4) Excitatory longitudinal muscle motor neurons (25%) (5) Inhibitory longitudinal muscle motor neurons (2%) (6) Excitatory circular muscle motor neurons (12%) (7) Inhibitory circular muscle motor neurons (16%) (8) Descending interneurons local reflex (5%) (9) Descending interneurons (2%): secretomotor reflex (10) Descending MMC interneurons (4%)
NAL Submucosal neurons 4o 9 10 (II) Submucosal intrinsic primary cH afferent neurons(11%) sM(12) Non-cholinergic Arte M secretomotor/vasodilator neurons Gland (45%) (13 )Cholinergic LM: longitudinal muscle: MP secretomotor/vasodilator neurons myenteric plexus; CM: circular muscle SM: submucosal plexus: Muc: mucosa (15%) 14) Cholinergic secretomotor (non-vasodilator) neurons(29%)
7 LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa Submucosal Neurons (11) Submucosal intrinsic primary afferent neurons (11%) (12) Non-cholinergic secretomotor/vasodilator neurons (45%) (13) Cholinergic secretomotor/vasodilator neurons (15%) (14) Cholinergic secretomotor (non-vasodilator) neurons (29%)
2. Characteristics of intrinsic primary afferent neurons (IPANs) ☆ Shape: round or oval Synaptic Modulation 么-☆ Processes: multi- axonal or Axon Refe pseudounipolar(假单极) Transmisson to Transcellular oter neurons Conduction s☆ gnal Conduction >traverse the cell bodies M (transcellular conduction) >can be conducted to output synapses via an axon reflex(axon reflex onduction) transcellular conduction can be modified by the ynaptic inputs that it receives
8 2. Characteristics of intrinsic primary afferent neurons (IPANs) ❖Shape: round or oval ❖Processes: multi-axonal or pseudounipolar(假单极) ❖Signal Conduction: ➢traverse the cell bodies (transcellular conduction) ➢can be conducted to output synapses via an axon reflex (axon reflex conduction). ➢ transcellular conduction can be modified by the synaptic inputs that it receives
2. Characteristics of IPANs-Conti Communication 10 >with other neurons in the @书 myenteric and submucosal Arteriole Mud ganglia Gland 2 Myenteric intrinsic primary afferent neurons(26%)
9 2. Characteristics of IPANs- Conti ❖Communication: ➢with other neurons in the myenteric and submucosal ganglia. 2 Myenteric intrinsic primary afferent neurons (26%)
2. Characteristics of intrinsic afferent neurons - Conti Ca hump (N-type channel gNa. (TTX. Early AHP Na、( non TTx gca ADP Late AHP gCAN g(K, Na (IK channels (Caesium ☆ Electrophysiology K。,BK AHP current) IH current delayed rectifier Broad action potential carried by both sodium and calcium current >Followed by early and late(slow )afterhyperpolarizing potential AHP
10 2. Characteristics of intrinsic afferent neurons- Conti ❖Electrophysiology ➢Broad action potential carried by both sodium and calcium current ➢Followed by early and late (slow) afterhyperpolarizing potential (AHP)