有机化学 Organic chemistry 2010 For Undergraduates in biological science 王俊儒张继文袁茂森 应用化学系416,417室 87092187(0) By Junru Wang Email:wangjr07@163.com
Organic Chemistry,6h Edition L.G.Wade,Jr. Chapter 7 Alkyl Halides:Nucleophilic Substitution and Elimination By Junru Wang Email:wangjr07@163.com
Content Preparation and physical properties Nucleophilic substitution Factors affecting SN2 versus SN1 reactions ■Elimination Elimination versus substitution Reactions of alkyl halides Organometallic reactions
Key Notes Nucleophilic Substitution ●SN1 ●SN2 ■Elimination(E1,E2) ■Nucleophilicity .The rate of the SN2 reaction increases with the nucleophilic strength of the incoming nucleophile. .The rate of the SN1 reaction is unaffected by the nature of the nucleophile ■Leaving group
Classes of Halides Alkyl:Halogen,X,is directly bonded to sp3 carbon. Vinyl:X is bonded to sp2 carbon of alkene. Aryl:X is bonded to sp2 carbon on benzene ring.Examples: HH H H-C-C-Br C-C HH H alkyl halide vinyl halid aryl halide