Hyperthermia treatment for tumors
Hyperthermia treatment for tumors
Measurement principle Small amount heat deposition Temperature increment Heat transfer due to conduction (k:)&advection (wp) Geometry B.C.s Model predicted temp. Measured temp. Comparison LSR fit, adjustment of wpr kt Wor kt
Small amount heat deposition Temperature increment Heat transfer due to conduction (k t) & advection (w b ) Model predicted temp. Measured temp. Comparison LSR fit, adjustment of w b, k t w b, k t Geometry B.C.s Measurement principle
Hyperthermia treatment for tumors 'Tumor Microenvironment Microvasculature Stage of tumor: Inhibitors 1.Dormant (no vasculature) 2.Vascularization (inducer:vascular growth factors) 3.Growth and Metastasis (new tumors) 4.Suppression of new tumors(inhibitors from main tumor), Necrotic(less perfusion in tumor center(in animal at least)- >average perfusion decrease)
Hyperthermia treatment for tumors •Tumor Microenvironment & Microvasculature • Stage of tumor: 1. Dormant (no vasculature) 2. Vascularization (inducer: vascular growth factors) 3. Growth and Metastasis (new tumors) 4. Suppression of new tumors (inhibitors from main tumor), Necrotic (less perfusion in tumor center (in animal at least) ‐ >average perfusion decrease)
I.E. w256 Carcinosarcoma in rats (R.K.Jain,1977) Wo=WoN in necrotic zone =10 WoN in viable zone Canine lymphosarcoma(Tuttle et.al.1964;Straw etal, 1974) Wb=1.2+15.1(r/R)2ml/min/g
I.E. w256 Carcinosarcoma in rats (R.K. Jain, 1977) Wb= WbN in necrotic zone =10 WbN in viable zone Canine lymphosarcoma (Tuttle et. al. 1964; Straw etal, 1974) Wb=1.2+15.1(r/R)2 ml/min/g
Therapeutic approaches: Anti-angiogenic drug (Dr.Moses.J.Folkman Boston Children's Hospital May,1998. Newa week Blood supply↓ Hyperthermia
Therapeutic approaches: Blood supply ↓ Anti-angiogenic drug (Dr. Moses.J.Folkman Boston Children’s Hospital May, 1998. Newa week Hyperthermia