Hyperthermia effect 1866(Busch):erysipelas (insect)attack >high fever>cure for a facial sarcoma 189l(Coley小：bacterial toxins→high fever(cancer patients) →reduced cancer size 1900:experiments done in lab animals>thermal dose (elevated temp.,duration)>effective treatment
Hyperthermia effect 1866(Busch): erysipelas (insect) aƩack →high fever → cure for a facial sarcoma 1891(Coley): bacterial toxins → high fever (cancer paƟents) → reduced cancer size 1900: experiments done in lab animals → thermal dose (elevated temp., duraƟon) → effecƟve treatment
1970s&1980s: Exp.studies at the cellular level> tumor cells are more sensitive to heat than normal cells due to abnormal molar ratios of cholesterol phospholipid Elevated temperature at 43C for a period of time is more lethal to tumor cells. cholesterol phospholipid↑→heat resistance of cells↑
1970s&1980s: Exp. studies at the cellular level → • tumor cells are more sensitive to heat than normal cells due to abnormal molar ratios of cholesterol phospholipid • Elevated temperature at 43Ԩ for a period of time is more lethal to tumor cells. cholesterol phospholipid↑ → heat resistance of cells ↑
1980s-present Numerous Exp Clinical trials Hyperthermia alone->partial reduction of tumor size Hyperthermia w/ionized (reduced hypoxia)radiation therapy better results Hyperthermia (increased circulation,increased vascular wall permeability to drugs)->better results
1980s‐present • Numerous Exp & Clinical trials • Hyperthermia alone‐>partial reduction of tumor size • Hyperthermia w/ ionized (reduced hypoxia) radiation therapy ‐ > better results • Hyperthermia (increased circulation, increased vascular wall permeability to drugs) ‐> better results
Effective Hyperthermia treatment a.Heating source selection: Surface Heating (local or whole body)-"Boundary condition" Hot water bath or moist air incubator ● Space suit and blanket techniques ● Infrared radiation ● Hot wax bath(molten paraffin wax having melting point of 46C) ● Regional systemic perfusion with heated blood Implantation of a heat source and electrocoagulation
Effective Hyperthermia treatment a. Heating source selection: Surface Heating (local or whole body)‐”Boundary condition” • Hot water bath or moist air incubator • Space suit and blanket techniques • Infrared radiation • Hot wax bath (molten paraffin wax having melting point of 46Ԩ) • Regional & systemic perfusion with heated blood • Implantation of a heat source and electrocoagulation