ligand-gated ion channels in Axon of channel Ission Action ated Ca2 lining acetylcholine kU Cell bo neuron Acetylcholine
Role of voltage-gated and ligand-gated ion channels in neural transmission
hree states of the acetylcholine receptor II. Acetylcholine binding sites Na+ Ca2+ ACh Continued excitation Outside Inside Resting Excited Desensitized (gate closed) (gate open (gate closed ACh
Three states of the acetylcholine receptor
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
General introduction Ion channels G-protein coupled receptors Second messengers Tyrosine kinase receptors From plasma membrane to the nucleus: Regulation of gene expression Cytokine signaling Cell cycle Apoptosis Cell signaling and diseases
Ligand-activated cell-surface receptors lon-channel receptors: acetylcholine G-protein-coupled receptors: epinephrine, glucagon, serotonin Tyrosine kinase-linked receptors: EGF, PDGF, interferons, insulin Tyrosine phosphatase receptors: CD45 Serine/therinine kinase receptors: TGFB, BMP Guanylate cyclase receptor: atrial naturetic factor
Ligand-activated cell-surface receptors Ion-channel receptors: acetylcholine G-protein-coupled receptors: epinephrine, glucagon, serotonin Tyrosine kinase-linked receptors: EGF, PDGF, interferons, insulin Tyrosine phosphatase receptors: CD45 Serine/therinine kinase receptors: TGFb, BMP Guanylate cyclase receptor: atrial naturetic factor
Spinel HO OH HO CH—CH2-NH2 CH3 Epinephrine Produced by chromaffin cells in adrenal medulla Functions Increase heart rate, blood pressure sweating, rate of respiration Stimulate conversion of glycogen to glucose
Epineph rine Produced by Chromaffin cells in adrenal medulla Functions: Increase heart rate, blood pressure, sweating, rate of respiration Stimulate conversion of glycogen to glucose