After a potential new drug substance is discovered d)A great deal of biologic information must be gathered basic pharmacology toxicologic features ADME short term and long term effects of the drug on various body cells, tissues and organs
After a potential new drug substance is discovered 1) A great deal of biologic information must be gathered • basic pharmacology • toxicologic features • ADME • short term and long term effects of the drug on various body cells, tissues and organs
2)The most effective routes of administration must be determined And Guidelines for dosages recommended for Persons of varying ages(eg neonates, children, adults, geriatrics) Weights States of illness have to be established
2) The most effective routes of administration must be determined • And Guidelines for dosages recommended for • Persons of varying ages (e.g., neonates, children, adults, geriatrics) • Weights • States of illness • have to be established
3)Formulation Active therapeutic ingredients fillers THickeners Solvents Suspending agents · Tablet coatings · Disintegrants Stabilizing agents Antimicrobial preservatives Flavors Colorants sweeteners
3) Formulation • Active therapeutic ingredients • Fillers • Thickeners • Solvents • Suspending agents • Tablet coatings • Disintegrants • Stabilizing agents • Antimicrobial preservatives • Flavors • Colorants • sweeteners
4)Stability the principles of chemistry, ° physical pharmacy, microbIology, pharmaceutical technology must be applied
4) Stability • the principles of chemistry, • physical pharmacy, • microbiology, • pharmaceutical technology must be applied
1. The heritage of Pharmacy Early drugs e Ebers papyrus, a continuous scroll 16th century 埃伯斯纸草文稿 G The text of the ebers papyrus is dominated by drug formulas, with more than 800 formulas or prescriptions being described and more than 700 drugs mentioned
1. The Heritage of Pharmacy Early drugs Ebers papyrus, a continuous scroll (16th century)-埃伯斯纸草文稿 The text of the Ebers papyrus is dominated by drug formulas, with more than 800 formulas or prescriptions being described and more than 700 drugs mentioned