苏州大学医学部药学院授课教案 授课教师：叶娜 授课日期：2020.10.13 课程名称 Medicinal Chemistry 所属学科 药学 医18药学3 教材名称 Foye's Principles of Medicinal Chemistry, 7th edition 授课年级 (全英文方 向) 授课章节 Chapter 15.Sedative-Hypnotics 授课时间 2课时 一、 教学目标：含知识目标、技能（能力）目标 1.知识目标： (1) Get a general idea about anxiety and insomnia.Understand the development history of anxiolytics and sedative-hypnotics. (2) To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major anxiolytics and sedative- hypnotics; (3) Understand the synthesis and metabolism of anxiolytics and sedative- hypnotics. 2.技能（能力）目标：结合实验课程目标
苏州大学医学部药学院授课教案 授课教师： 叶娜 授课日期：2020.10.13 课程名称 Medicinal Chemistry 所属学科 药学 教材名称 Foye’s Principles of Medicinal Chemistry, 7th edition 授课年级 医 18 药学 3 （全英文方 向） 授课章节 Chapter 15. Sedative-Hypnotics 授课时间 2 课时 一、 教学目标：含知识目标、技能（能力）目标 1. 知识目标： （1） Get a general idea about anxiety and insomnia. Understand the development history of anxiolytics and sedative-hypnotics. （2） To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major anxiolytics and sedativehypnotics; （3） Understand the synthesis and metabolism of anxiolytics and sedativehypnotics. 2. 技能（能力）目标：结合实验课程目标
授课内容（依据教学大纲）及时间分配 Get a general idea about anxiety and insomnia. 6min Get a general idea about GABA and its functions and neurochemistry 6 min Get a general idea about the distribution,structures and functions of GABA receptor. 10 min Get a general idea about Melatonin and its functions and neurochemistry 8 min Get a general idea about the distribution,structures and functions of Melatonin receptor. 10 min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major anxiolytics and sedative-hypnotics;Understand the synthesis and metabolism of anxiolytics and sedative-hypnotics. Including the following specific drugs(60 min): Agents that cause CNS depression via agonism of GABAA receptors:Barbiturates;Benzodiazepines(e.g.Chlodiazepoxide, Diazepam);Nonbenzodiazepines (e.g.Zolpidem,esZopiclone, Zaleplon) 40 min Agents that modulate melatonin circadian systems:Ramelteon, Tasimelteon. 20 min 三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major anxiolytics and sedative-hypnotics
二、 授课内容（依据教学大纲）及时间分配 Get a general idea about anxiety and insomnia. 6 min Get a general idea about GABA and its functions and neurochemistry 6 min Get a general idea about the distribution, structures and functions of GABA receptor. 10 min Get a general idea about Melatonin and its functions and neurochemistry 8 min Get a general idea about the distribution, structures and functions of Melatonin receptor. 10 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major anxiolytics and sedative-hypnotics; Understand the synthesis and metabolism of anxiolytics and sedative-hypnotics. Including the following specific drugs (60 min): Agents that cause CNS depression via agonism of GABAA receptors: Barbiturates; Benzodiazepines (e.g. Chlodiazepoxide, Diazepam); Nonbenzodiazepines (e.g. Zolpidem, esZopiclone, Zaleplon) 40 min Agents that modulate melatonin circadian systems: Ramelteon, Tasimelteon. 20 min 三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major anxiolytics and sedative-hypnotics
2.教学难点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major anxiolytics and sedative-hypnotics 四、 教学方法选择 13.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题) 14.实验教学：（简要列出实验内容标题）
2. 教学难点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major anxiolytics and sedative-hypnotics 四、 教学方法选择 13. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题） 14. 实验教学：（简要列出实验内容标题）
五、 更新或补充内容提要 六、 复习思考题 Valium is easy to be hydrolyzed under acidic condition,leading to instability and short duration of time.Point out chemically unstable sites of Valium and write the possible chemical reactions,and provide suggestions for further structural modifications?If you can write down the structure of the drug, you will get extra points. 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期肝刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
五、 更新或补充内容提要 六、 复习思考题 Valium is easy to be hydrolyzed under acidic condition, leading to instability and short duration of time. Point out chemically unstable sites of Valium and write the possible chemical reactions, and provide suggestions for further structural modifications? If you can write down the structure of the drug, you will get extra points. 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
苏州大学医学部药学院 教 案 课程名称： 药物化学英文班 授课对象： 药学英文班3年级本科生 授课学时： 90 Foye's Principles of 教材版本： Medicinal Chemistry,7th edition 主讲教师： Xiaoyan Qiu 苏州大学医学部药学院制 2020年10月26日
苏州大学医学部药学院 教 案 课程名称： 药物化学英文班 授课对象： 药学英文班 3 年级本科生 授课学时： 90 教材版本： Foye’s Principles of Medicinal Chemistry, 7th edition 主讲教师： Xiaoyan Qiu 苏州大学医学部药学院制 2020 年 10 月 26 日