1.Tight junction interacting plasma membranes The only occluding junction; Widely distributed in all kinds of epithelia cells, intercellular space 0.6um Claudin,occludin,and ZO protein constitute sealing sealing strands; strands of tight- The degree of sealing junction proteins differs between different tissues. cytoplasmic half of lipid bilayer cell cell 6 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
The structure of a tight junction between epithelial cells of the small intestine microvilli intestinal lumen (E face) cell 1 cell 2 focal connection focal connection plasma tight membrane junction (B) (A) ridges of transmembrane lateral plasma 0.5um 50nm particles forming sealing membrane strands(P face) 7 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more informatior
A model of a tight junction cell 1 UF UU cell 2 claudin occludin tight-junction proteins 8 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Function of tight junction Seal the gap between epithelia,isolate the tissue and outside,prevent material transition,ensure the environmental stability within the organization. The barrier to prevent lateral diffusion of membrane lipids and protein,keep the polarity of epithelial cells. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
The role of tight junctions in transcellular transport Na+-driven glucose symport apical surface LOW LUMEN glucose OF GUT tight junction HIGH plasma glucose membranes of adjacent cells glucose concentration intercellular space passive glucose carrier protein basolateral cell surface cell cell basal lamina EXTRACELLULAR FLUID/CONNECTIVE glucose LOW TISSUE BLOOD This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information