B cells and humoral immune response Recognition of the specific Ag 2. Activation proliferation differentiation 2. Germinal center: laterevent 3. General feature of Ab response
B cells and humoral immune response 1. Recognition of the specific Ag 2. Activation, proliferation, differentiation 2. Germinal center: later event 3. General feature of Ab response
1) activation A. 2-signal activation model B the help from Th cell 2)Signal transduction 3Proliferation and differentiation
1) activation A. 2-signal activation model B. the help from Th cell 2) Signal transduction 3) Proliferation and differentiation
the 2-signal rule signal 1: BCR B cell epitope signal 2: CD40- CD40 L Co-sti mol B Th CD40L survIve B7 survIve
the 2-signal rule signal 1：BCR － B cell epitope signal 2：CD40 － CD40 L B Th Co-sti mol CD40L survive B7 survive
B cell activation requires 2 signals H Ce CD40/CD40L O B cell Signal 3: IL-4
B cell activation requires 2 signals Signal 3: IL-4
Signal 1 From antigen Recognition of Receptor-mediated Ag endocytosis B cell epitope T cell epitope-MHC ll presentation ① CD40 BCR serves 2 roles Ag-induced clustering of BCRs delivers signals that initiate the activation process 2. BCR internalize the ag into endosome, process and present on surface for t recognition
Signal 1 From antigen BCR serves 2 roles: 1. Ag-induced clustering of BCRs delivers signals that initiate the activation process. 2. BCR internalize the Ag into endosome, process and present on surface for T recognition Receptor-mediatedAg endocytosis T cell epitope-MHC II presentation B cell epitope Recognition of