28.2 Transforming viruses carr Viral infection oncogenes viral genes enter germline Figure 28.6 Retroviruses transfer genetic information horizontally by infecting new hosts information is inherited All cells of progeny carry vertically if a virus endogenous virus integrates in the genome of the germline 消当
Figure 28.6 Retroviruses transfer genetic information horizontally by infecting new hosts; information is inherited vertically if a virus integrates in the genome of the germline. 28.2 Transforming viruses carry oncogenes
RNA 28.2 Transforming Reverse viruses carr transcription LTR LTR oncogenes Linear DNA A Figure 16. 2 The retroviralntegration Circul arization life cycle proceeds by reverse transcribing the RNA genome into duplex DNA. which is inserted Provirus ANNA into the host genome, in order to be transcribed intoTranscription RNA RNA 消当
Figure 16.2 The retroviral life cycle proceeds by reverse transcribing the RNA genome into duplex DNA, which is inserted into the host genome, in order to be transcribed into RNA. 28.2 Transforming viruses carry oncogenes
28.2 Transforming viruses carry oncogenes Original virus RU5 gad erw U3 Figure 28.7A transforming retrovirus carries a Transforming virus copy of a cellular RU5 gag U3 sequence in place of some of its own Copy of spliced cellular gene gene(s) 消当 Gag-onc fusion protein
Figure 28.7 A transforming retrovirus carries a copy of a cellular sequence in place of some of its own gene(s). 28.2 Transforming viruses carry oncogenes
28.3 Retroviral oncogenes have cellular counterparts Proto-oncogenes are the normal counterparts in the eukaryotic genome to the oncogenes carried by some retroviruses. They are given names of the form c-onc 消当
Proto-oncogenes are the normal counterparts in the eukaryotic genome to the oncogenes carried by some retroviruses. They are given names of the form c-onc . 28.3 Retroviral oncogenes have cellular counterparts
28.3 Retroviral oncogenes have cellular counterparts Virus Name Species Tumor oncogene Rous sartor RSV chicken sarcoma Src Harvey munne sarcoma Ha-MuSv rat sarcoma& erythroleukemia H-ras Kirsten m urine sarcom a ki-Musv sarcoma& erythroleukemia K-ras Moloney munine sarcomaMo-Musv mouse sarcoma mos FBJ m urine osteosarcom BJ-MuSy mouse chondrosarcoma a fos Sim ian sarcom a SSV monkey sarcoma S/S Feline sarcoma PI-Fesv cat sarcoma SIS Feline sarcoma SM-Fesv cat fibrosarcoma fms Feline sarcoma ST-Fesv cat fibrosarcoma fes Aⅵ an sarcoma Asv-17 chicken fibrosarcoma Fujinami saroom a BuSY chicken sarcoma AMan m yelocytomatosis MC29 chicken carcinom a, sarcoma, m yelocytonye Abelson leukemia MuLY mouse B cell lymphoma a Reticuloendotheliosis REV-T turkey lym phat ic leukemia res Avan erythroblastosis AEV chicken erythroleukemia fbrosarcom a ebB, erbA Avan m yeloblastosis AMV chicken m yeloblastic leukemia myb Figure 28.8 Each transforming retrovirus carries an oncogene derived from a cellular gene. Viruses have names and abbreviations reflecting the history of their isolation and the types of tumor they cause. This ist shows some representative examples of the retroviral oncogenes 消当
Figure 28.8 Each transforming retrovirus carries an oncogene derived from a cellular gene. Viruses have names and abbreviations reflecting the history of their isolation and the types of tumor they cause. This list shows some representative examples of the retroviral oncogenes 28.3 Retroviral oncogenes have cellular counterparts