2. Water balanceNutrientsoxidationDigestiveICFtractsInterstitialPlasma40%BW15%5%Kidney(urine)1500mlIntestine(feces)200mlWaterlossLung(watervapor) 400mlSkin(sweat and evaporation)400mlWater balance
Water balance Intake Output 15% 40% BW 5% Interstitial Plasma ICF Kidney(urine) 1500ml Intestine(feces) 200ml Lung(water vapor) 400ml Skin(sweat and evaporation)400ml Digestive tracts Nutrients oxidation Water loss 2. Water balance
3.Body fluid distributes in body and shiftInterstitial 15% Plasma5%TranscellularfluidICF40%ECF20%
ICF40% ECF20% 3.Body fluid distributes in body and shift Interstitial 15% Plasma 5% Transcellular fluid
Osmolality of the body fluidAcquaporinICFECF[Na+]140mmol/LK+4.5mmol/LK+150mmol/LDirection of water shifting
Osmolality of the body fluid ECF ICF Direction of water shifting Acquaporin K+ 150mmol/L K+ 4.5 mmol/L [Na+] 140mmol/L
4. Regulation of fluid volume and osmotic pressureRegulation pathwayDisturbanceADHRAASANPVolumeguanylinThirstOsmoticpressureThirstADHRAASguanylin
4. Regulation of fluid volume and osmotic pressure Disturbance Volume Osmotic pressure ADH RAAS ANP guanylin Thirst Thirst ADH RAAS guanylin Regulation pathway
(1)The sensation of thirsty(2)Hormonesetheguanylin familynewhormone
(1)The sensation of thirsty (2)Hormones new hormone the guanylin family