●●●●● ●●●● ●●0 ●●● ●●●● e An extended-release dosage forms are defined as one that allows a reduction in do sing frequency to that presented by a conventional dosage form o a delayed -release dosage form is designed to release the drug from the dosage form at a time other than promptly after administration The delay may be time-based or based on the influence of environmental conditions as gastrointestinal ph
⚫ An Extended-release dosage forms are defined as one that allows a reduction in dosing frequency to that presented by a conventional dosage form. ⚫ A Delayed-release dosage form is designed to release the drug from the dosage form at a time other than promptly after administration. The delay may be time-based or based on the influence of environmental conditions, as gastrointestinal pH
●●●●● ●●●● ●●0 ●●● ●●●● o Repeat-action forms usually contain two single doses of medication, one for immediate release and the second for delayed release Targeted release describes drug release directed toward isolating or concentrating a drug in a body region, or site for absorption or for drug action
⚫ Repeat-action forms usually contain two single doses of medication, one for immediate release and the second for delayed release. ⚫ Targeted release describes drug release directed toward isolating or concentrating a drug in a body region, or site for absorption or for drug action
II. Extended-release oral dosage ●●●●● ●●●● ●●0 ●●● forms ●●●● 1. Drug-candidates for extended-release products The drugs best suited for incorporation into an extended-release product have the following characteristics They exhibit neither very slow nor very fast rates of absorption and excretion
III. Extended-release oral dosage forms 1. Drug-candidates for extended-release products The drugs best suited for incorporation into an extended-release product have the following characteristics: - They exhibit neither very slow nor very fast rates of absorption and excretion
●●●●● ●●●● ●●0 ●●● ●●●● They are uniformly absorbed from the gastrointestinal tract. They are administered in relatively small doses They possess a good margin of safety. They are used in the treatment of chronic rather than acute conditions
- They are uniformly absorbed from the gastrointestinal tract. - They are administered in relatively small doses. - They possess a good margin of safety. - They are used in the treatment of chronic rather than acute conditions
2. Extended-release technology for ●●●●● ●●●● ●●0 oral dosage forms ●●● ●●●● The rate of drug release from solid dosage forms may be modified by the technologies described below Modifying drug dissolution by controlling access of biologic fluids to the drug through the use of barrier coatings
The rate of drug release from solid dosage forms may be modified by the technologies described below: - Modifying drug dissolution by controlling access of biologic fluids to the drug through the use of barrier coatings. 2. Extended-release technology for oral dosage forms