Surface functional mole cules sMHC、 molecules 4 co-stimulatory molecules #e CD40: most important csm for B cell activation B cell CD40 CD40L T cell
♣ MHC-I、II molecules ♣ co-stimulatory molecules Surface functional molecules CD40: most important csm for B cell activation B cell T cell CD40 CD40L
Two-signal activation model for T cells CD4 ① MTHCⅡ肽TCR activation BT CD28 APC co-stimulatory naive CD4T T molecules none anergy
Two-signal activation model for T cells naive activation co-stimulatory molecules none anergy
Two-signal activation model for B cells Thymus-dependent antigen Helper T celll CD4OL (cD154 CD40 cytokines Signal 1 and signal 2 are not simultaneous Signal 3 But in two steps, signal 2 from Th cells
Two-signal activation model for B cells Signal 1 and signal 2 are not simultaneous But in two steps, signal 2 from Th cells Signal 3