Two important sources for mutation(unavoidable) a Inaccuracy in DNA replication (10-7 is not accurate enough) Errors(错误) a Chemical damage to the genetic material (environment) Lesions(损害伤害 arose from spontaneous damage) Damage(损害伤害 caused by chemical agents and radiation
Two important sources for mutation (unavoidable) ◼ Inaccuracy in DNA replication (10-7 is not accurate enough) Errors (错误) ◼ Chemical damage to the genetic material (environment) Lesions (损害,伤害arose from spontaneous damage) Damage (损害,伤害 caused by chemical agents and radiation
To repair an error or damage First, detect the errors Second, mend/ repair the errors or lesions in a way to restore the original dNa sequence
To repair an error or damage First, Detect the errors Second, Mend/repair the errors or lesions in a way to restore the original DNA sequence
Questions to be addressed 1. How is the dNa mended rapidly enough to prevent errors from becoming set in the genetic material as mutation 2. How does the cell distinguish the parental strand from the laughter strand in repairing replication errors
Questions to be addressed 1. How is the DNA mended rapidly enough to prevent errors from becoming set in the genetic material as mutation 2. How does the cell distinguish the parental strand from the daughter strand in repairing replication errors
3. How does the cell restore the proper DNa sequence when the original sequence can no longer be read? 4. How does the cell deal with lesions that block replication?
3. How does the cell restore the proper DNA sequence when the original sequence can no longer be read? 4. How does the cell deal with lesions that block replication?
ChATER 9 The mutability and repair of Dna Topic 1: Replication errors and their repair 1. How the replication errors are resulted? 2 What is the nature of the replication errors? 3. How they are recognized and correctly repair? 劣溪字 Wuhan Universit
Topic 1: Replication errors and their repair CHAPTER 9 The mutability and repair of DNA 1. How the replication errors are resulted? 2. What is the nature of the replication errors? 3. How they are recognized and correctly repair?