Immunologic Tolerance o General Features and Mechanisms o T Lymphocyte Tolerance o B Lymphocyte Tolerance o Tolerance induced by Foreign Protein Antigens o Homeostasis in the Immune System
Immunologic Tolerance ⚫ General Features and Mechanisms ⚫ T Lymphocyte Tolerance ⚫ B Lymphocyte Tolerance ⚫ Tolerance induced by Foreign Protein Antigens ⚫ Homeostasis in the Immune System
T Lymphocyte Tolerance O Central T cell Tolerance o Peripheral T cell Tolerance
T Lymphocyte Tolerance ⚫ Central T Cell Tolerance ⚫ Peripheral T cell Tolerance
Maturation of t cells in the thymus ule Dead cell Trabecula Thymocyte Nurse cell Dividing thymocyte Cortical epithelial ⊙ 29 Interdigitation dendritic cell Blood vessel Medullary epithelial cell Macrophage Hassall,s corpuscles
Maturation of T cells in the thymus
Negative selection: Development of central tolerance Positive Selection Negative Selection CD4 CD8. CD4 CD8. CD4 CD4·cD8 TEC CD4 CD8* apoptosis CD4'CD8 cD4·cD8 CD4·cD8 CD4'CD8 apoptosis High affinity i uch concentration Hi h ig
Negative selection: Development of central tolerance
Self antigens expressed in the thymus o ubiquitous self-antigen: widely expressed in the body o tissue-specific antigen autoimmune regulator gene, AIRE
Self antigens expressed in the thymus ⚫ ubiquitous self-antigen: widely expressed in the body ⚫ tissue-specific antigen autoimmune regulator gene, AIRE