1910S-1930s, Gustav Embden and otto Meyerhof (Germany), studied muscle and its extracts Reconstructed all the transformation steps from glycogen to lactic acid in vitro revealed that many reactions of lactic acid (muscle)and alcohol (yeast) fermentations were the same Discovered that lactic acid is reconverted to carbohydrate in the presence of O2 (gluconeogenesis); observed that some phosphorylated compounds are energy-rich
• 1910s-1930s, Gustav Embden and Otto Meyerhof (Germany), studied muscle and its extracts: – Reconstructed all the transformation steps from glycogen to lactic acid in vitro; revealed that many reactions of lactic acid (muscle) and alcohol (yeast) fermentations were the same! – Discovered that lactic acid is reconverted to carbohydrate in the presence of O2 (gluconeogenesis); observed that some phosphorylated compounds are energy-rich
Glycolysis was also known as Embden-Meyerhof pathway. The whole pathway of glycolysis (Glucose to pyruvate) was elucidated by the 1940s
• Glycolysis was also known as Embden-Meyerhof pathway. • The whole pathway of glycolysis (Glucose to pyruvate) was elucidated by the 1940s
The Nobel Prize in Chemistry 1907 for his biochemical researches and his discovery of cell-free fermentation Eduard Buchner Germany Landwirtschaftliche Hochschule (Agricul tural College) Berlin, Germany 1860-1917
Arthur Harden 1865-1940 William Young l878-19492
The nobel Prize in Chemistry 1929 for their investigations on the fermentation of sugar and fermentative enz ymes Presentation Speech Sir Arthur Harden Great Britain London University London Great Britain 1865-1940 Hans von Euler-Chelpin Stockholm University Stockholm, Sweden 1873-1 Biography Swedish Nobel Stamps