a.In blood vessels b.in the heart c.in the lungs (bronchial smooth muscle) d.In the eye e.Salivary glands f.presynaptic regulation 长Mo2rscenosaendne a.Direct effect on receptors b.Influence the Biosynthesis,Metabolism,Transfer and St orage of the ne urotransmitter x.Classification of autonomic nervous system drugs a.Cholinergic nerve agonists b.Cholinergic nerve antagonists c.Adrenergic nerve agonists d adrenergic nerve antagonists xi.Function of auton omicnervous system a.Functions of the sympathetic system: b.Functions of the parasympathetic system Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Total hours required Total Classes required Days of Study Tue.Wed Period of Study Week 3&4-First semester a.Lecture 1 Class XI i.Mode of action of cholinomimetic drugs ii.The classification of cholinoceptor agonist a.Muscarinic receptors stimulants:pilocarpine b.N icotinic receptors stimulants:nicotine c.Muscarinic and nicotinic receptors stimulants iii.Organ system effect of muscarinic receptors stimulants a Eve b.Cardiovascular system- .Smooth muscle:Constriction of smooth muscle d.Glands iv.Organ system effect of nicotinic receptors stimulants a.Central nervous system- b.Peripheral nervous system- c.Neuromuscular junction-
a. In blood vessels b. in the heart c. in the lungs (bronchial smooth muscle) d. In the eye e. Salivary glands: f.presynaptic regulation g.postsynaptic regulation ix. Mode of action of autonomic nervous system drugs a. Direct effect on receptors b.Influence the Biosynthesis, Metabolism, Transfer and Storage of the Neurotransmitter. x. Classification of autonomic nervous system drugs a. Cholinergic nerve agonists b. Cholinergic nerve antagonists c. Adrenergic nerve agonists d. Adrenergic nerve antagonists xi. Function of autonomicnervous system a.Functions of the sympathetic system: b.Functions of the parasympathetic system Cholinoceptor-Activating and Cholinesterase-Inhibiting Drugs Total hours required = 4 Total Classes required = 2 Days of Study = Tue, Wed Period of Study = Week 3&4 –First semester a. Lecture 1 Class XI i. Mode of action of cholinomimetic drugs ii. The classification of cholinoceptor agonist a.Muscarinic receptors stimulants: pilocarpine b.N icotinic receptors stimulants: nicotine c.Muscarinic and nicotinic receptors stimulants iii. Organ system effect of muscarinic receptors stimulants a. Eye b. Cardiovascular systemc..Smooth muscle: Constriction of smooth muscle d. Glands iv.Organ system effect of nicotinic receptors stimulants a.Central nervous systemb.Peripheral nervous systemc.Neuromuscular junction-
b.Lecture 1 Class XII i.The classification of the cholinesterases a.Acetylcholinesterase:ACH b.Pseudocholinesterase:succinylcholine ii.The classification of cholinesterase inhibitors a.Reversible cholinesterase inhibitors(physostigmine. neostigmine) b.Irreversible cholinesterase inhibitors(organophosphate) iii.Organ system effect of cholinesterase inhibitors a.Central nervous system b.Eye,respiratory tract,gastrointestinal tract c.Cardiovascular system d.Neuromuscular junction- iv.Clinical uses of the cholinomimetics a.The Eye 6 Gastrointestinal and urinary tracts c.Neuromuscular Junction d.Heart: e.Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b.Direct-Acting Nicotinic Stimulants: c.Cholinesterase Inhibitors vi Specific cholinomimetic drugs a.M-cholinoceptor Agonists:Pilocarpine b.Cholinesterase Inhibitors:Neostigmine (Prostigmine) c.Cholinesterase Inhibitors:Organophosphates Cholinoceptor-Blocking Drugs ours required Total Classes required= Days of Study Thu Period of Study Week 1&2-First semester Lecture1 Class XIIⅢ i.The classification of cholinoceptor-blocking Drugs a.M receptors blocking Drugs b.N receptors blocking Drugs i Chemistry and Pharmacokinetics of the M receptors blocking drugs
b. Lecture 1 Class XII i. The classification of the cholinesterases a.Acetylcholinesterase: ACH b.Pseudocholinesterase: succinylcholine ii. The classification of cholinesterase inhibitors a. Reversible cholinesterase inhibitors(physostigmine, neostigmine) b. Irreversible cholinesterase inhibitors(organophosphate) iii. Organ system effect of cholinesterase inhibitors a. Central nervous system b. Eye, respiratory tract, gastrointestinal tract c. Cardiovascular system d. Neuromuscular junctioniv. Clinical uses of the cholinomimetics a. The Eye b. Gastrointestinal and urinary tracts c. Neuromuscular Junction d. Heart: e. Antimuscarinic Drug Intoxication v.Toxicity a..Direct-Acting Muscarinic Stimulants: b. Direct-Acting Nicotinic Stimulants: c. Cholinesterase Inhibitors vi Specific cholinomimetic drugs a. M-cholinoceptor Agonists : Pilocarpine b. Cholinesterase Inhibitors: Neostigmine (Prostigmine) c. Cholinesterase Inhibitors: Organophosphates Cholinoceptor-Blocking Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Thu Period of Study = Week 1&2 –First semester Lecture 1 Class XIII i. The classification of cholinoceptor -blocking Drugs a. M receptors blocking Drugs b. N receptors blocking Drugs ii. Chemistry and Pharmacokinetics of the M receptors blocking drugs
a.Source and chemistry: b.Absorption c Distribution and Excretion iii.Organ System Effects of the M receptors blocking drugs a.Eve- b.Cardiovascular system- c..Smooth muscle:Constriction of smooth muscle d Glands- e central neryous system iv.Clinical uses ofthe M receptors blocking drugs a.Central Nervous System Disorders(Parkinson's disease.Motion sickness) b.Ophthalmologic Disorders c.Relaxation of smooth muscle spasm d.Cardiovascular Disorders e Cholinergic Poisoning v.Adverse Effects of the M receptors blocking drugs vi.Contraindications of the M receptors blocking drugs vii.Organ System Effects of the Ni receptors blocking drugs a.Central nervous system b.Eye c.Cardiovascular system d.Gastrointestinal tract e.Other systems f Response to autonomic drugs- viii.Clinical uses of the Ni receptors blocking drugs ix.Adverse Effects of the Ni receptors blocking drugs x.Organ System Effects of the N2 receptors blocking drugs xi.Clinical uses of the N2 receptors blocking drugs xii.Adverse Effects of the N2 receptors blocking drugs Adrenoceptor-Activating Other sympathomimetic drugs Total hours required Total Classes required 2 Days of Study- Fri.Mon Period of Study Week 1&2-First semester a.Lecture 1 Class XIV i.The mode &spectrum of action of sympathomimetic drugs. a.Direct-acting agonists
a. Source and chemistry: b. Absorption c. Distribution: d. Metabolism and Excretion: iii. Organ System Effects of the M receptors blocking drugs a. Eyeb. Cardiovascular systemc..Smooth muscle: Constriction of smooth muscle d. Glandse.Central nervous system iv.Clinical uses of the M receptors blocking drugs a. Central Nervous System Disorders(Parkinson’s disease,Motion sickness) b. Ophthalmologic Disorders c. Relaxation of smooth muscle spasm d. Cardiovascular Disorders e. Cholinergic Poisoning v. Adverse Effects of the M receptors blocking drugs vi. Contraindications of the M receptors blocking drugs vii. Organ System Effects of the N1 receptors blocking drugs a. Central nervous system b. Eye c. Cardiovascular system d. Gastrointestinal tract e. Other systems f.Response to autonomic drugsviii. Clinical uses of the N1 receptors blocking drugs ix. Adverse Effects of the N1 receptors blocking drugs x. Organ System Effects of the N2 receptors blocking drugs xi. Clinical uses of the N2 receptors blocking drugs xii. Adverse Effects of the N2 receptors blocking drugs Adrenoceptor-Activating & Other sympathomimetic drugs Total hours required = 4 Total Classes required = 2 Days of Study = Fri, Mon Period of Study = Week 1&2 –First semester a. Lecture 1 Class XIV i. The mode &spectrum of action of sympathomimetic drugs. a. Direct-acting agonists
b.Indirect-acting agonist c.Mixed-action agonist ii.The identification of adrenoceptors iii.Chemistry pharmacokinetics of sympathomimetic drugs iv.The classification of adrenergic agonists v.Characte tics of adrenergic agonists a.Catecholamines b.Non-catecholamines vi.Organ system effects of sympathomimetic a.Cardiovascular system b.Eye c.Respiratory Tract d.Gastrointestinal Tract e.Genitourinary Tract f.Exocrine Glands Metabolic Effects sisouAooynaI puy uonsund auopuauo1333 i.Effect On The Central Nervous System vii.Clinical uses of sympathomimetic a.Cardiovascular Applications b.Respiratory Applications:Bronchial asthma c.Anaphylaxis d.Ophthalmic Applications e.Genitourinary Applications f.Central Nervous System Applications: g.Additional Therapeutic Uses ity of sympathomimetic drugs b.Lecture 2 Class XV i.Specific sympathomimetic drugs a.Mixed a and B agonists:Epinephrine b.o receptor agonists Norepinephrine .BReceptor Agonists Isoprenaline d.Dopamine Receptor Agonists:Dopamine Adrenoceptor Antagonist Drugs Total hours required= Total Classes required Davs of Study Tue Test= Wednesday Period of Study Week 1&2-First semester
b. Indirect-acting agonist c. Mixed–action agonist ii. The identification of adrenoceptors iii. Chemistry & pharmacokinetics of sympathomimetic drugs iv. The classification of adrenergic agonists v. Characteristics of adrenergic agonists a. Catecholamines b. Non-catecholamines vi. Organ system effects of sympathomimetic a. Cardiovascular system b. Eye c. Respiratory Tract d. Gastrointestinal Tract e. Genitourinary Tract f. Exocrine Glands g. Metabolic Effects h. Effect On Endocrine Function And Leukocytosis i. Effect On The Central Nervous System vii.Clinical uses of sympathomimetic a. Cardiovascular Applications b. Respiratory Applications: Bronchial asthma c. Anaphylaxis: d. Ophthalmic Applications e. Genitourinary Applications f. Central Nervous System Applications: g. Additional Therapeutic Uses: viii. Toxicity of sympathomimetic drugs b. Lecture 2 Class XV i.Specific sympathomimetic drugs a. Mixed and agonists : Epinephrine b. receptor agonists Norepinephrine c. Receptor Agonists Isoprenaline d. Dopamine Receptor Agonists : Dopamine Adrenoceptor Antagonist Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Tue Test= Wednesday Period of Study = Week 1&2 –First semester
Lecture 1 Class XVI 1.The classification of the adrenoceptor antagonist drugs ii.Pharmacologic effects of the a recepto antagonist drugs a.cardiovascular effects b.other effects iii.Clinical pharmacology of the a antagonist drugs iv.Specific agents:Phentolamine, Phenoxybenzamine,Prazosin Yohimbine v.Pharmacokinetic properties of the B antagonist drugs a.Abs orpti b.Bioavailability c.Distribution and clearance vi.Pharmacodynamics of the B R Antagonist Drugs a.Effects on the cardiovasular system b.Effects on the Respiratory Tract: c.Effects onthe Eye d.Metabolic and Endocrine Effects e.Intrinsic sympathomimetic activity (partial agonists) f effects not related to beta blockade vii.Clinical pha acolo r of the B ant aonist drugs viii.Clinical toxicity of the B antagonist drugs Sedative-Hypnotic Drugs Total hours required 2 Total Classes required Days of Study Tue Test= Wednesday Period ofStudy Week 1&2-First semester Lecture 1 Class XVI BASIC PHARMACOLOGY OF SEDATIVE- HYPNOTICS ii.CHEMICAL CLASSIFICATION iii.THE BENZODIAZEPINES BARBITURATES a.Pharmacokinetics i.Absorption ii.Distribution iii.Biotransformation iv.Excretion v.Factors Affecting Biodisposition
Lecture 1 Class XVI i. The classification of the adrenoceptor antagonist drugs ii. Pharmacologic effects of the recepto antagonist drugs a. cardiovascular effects b. other effects iii.Clinical pharmacology of the antagonist drugs iv. Specific agents: Phentolamine, Phenoxybenzamine,Prazosin ,Yohimbine v. Pharmacokinetic properties of the ß antagonist drugs a. Absorption b. Bioavailability c. Distribution and Clearance vi. Pharmacodynamics of the ß R Antagonist Drugs a. Effects on the cardiovasular system b. Effects on the Respiratory Tract: c. Effects on the Eye d. Metabolic and Endocrine Effects: e. Intrinsic sympathomimetic activity (partial agonists) f. Effects not related to Beta blockade vii. Clinical pharmacology of the ß antagaonist drugs viii. Clinical toxicity of the ß antagonist drugs Sedative-Hypnotic Drugs Total hours required = 2 Total Classes required = 1 Days of Study = Tue Test= Wednesday Period of Study = Week 1&2 –First semester Lecture 1 Class XVII i. BASIC PHARMACOLOGY OF SEDATIVEHYPNOTICS ii. CHEMICAL CLASSIFICATION iii. THE BENZODIAZEPINES & BARBITURATES a. Pharmacokinetics i. Absorption ii. Distribution iii. Biotransformation iv. Excretion v. Factors Affecting Biodisposition