Barriers for transdermal delivery }皮胙 C匚}角质层 生长表皮层 血管 表皮的模型结构
21 Barriers for transdermal delivery
Iontophoresis Iontophoresis(IP)is an electrochemical method that enhances the transport of some solute molecules by creating a potential gradient through the skin with an applied electrical current or VolTage 22
22 Iontophoresis • Iontophoresis (IP) is an electrochemical method that enhances the transport of some solute molecules by creating a potential gradient through the skin with an applied electrical current or voltage
E-TRANS electrotransport technolog 离子导入技术优势: 适用被动不能透皮吸收的药物 需要精确释放的药物 需要脉冲给药或病人自我控制的药物 复杂的给药模式:渐高,渐低,变化或 E-TRANSBelectrotransport 是循环方式 technology enables patient-controlled, pulsatile and macromolecule delivery through intact skin. 23
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Iontophoresis Negative Electrode voltage Positive Electrode neo. medication pos medication Tissue 24
24 Iontophoresis
1. An adhesive patch contains Active elecrode ReuTh clectrode a thin electrode and the drug-containing gel in skIn contact with the skin; 2. The battery-powered Drug microcontroller activates Entering 感kn the electrode with a mild current repelling the drug into the skin: 3. Depending on the dose and Cort rolled drug energy, the drug can act either locally or can be carried into the bloodstream
1. An adhesive patch contains a thin electrode and the drug-containing gel in contact with the skin; 2. The battery-powered microcontroller activates the electrode with a mild current repelling the drug into the skin; 3. Depending on the dose and energy, the drug can act either locally or can be carried into the bloodstream