Bioconⅰ agates DNA Labeling Protein/Peptide Labelin g Biotin-Antibod Enzyme-Antibody Protein-Antibody 16
16 Bioconjugates
Composition upon delivery to the target site and in the presence of certain enzymes or through hydrolysis or a comparable mechanism the bioconjugates can be cleaved releasing the active drug at a specific site of action 17
17 Composition • Upon delivery to the target site and in the presence of certain enzymes or through hydrolysis or a comparable mechanism the bioconjugates can be cleaved, releasing the active drug at a specific site of action
Many"Nanomedicines"are already in routine clinical use Antibodies and their Viruses as Liposomes viral vectors for Bangham, Gregorian Conjugates Celltech-UCB gene therapy polymer micelles Nanoparticles Nanomedicines NU Florence. Daves. Illum Polymer-protein Unimolecular Polymeric conjugates C Drugs and Conjugates Duncan
M Potential problems of the x polymers based systems A)Their high molecular weight may cause them to be very slowly excreted from the body B)Because of their size, permeability through various membranes may be slow C) Immunologic or toxic reactions may occur D) Since they are complex, they may be labor intensive and expensive to develop 19
19 Potential problems of the polymers based systems • A) Their high molecular weight may cause them to be very slowly excreted from the body, • B) Because of their size, permeability through various membranes may be slow • C) Immunologic or toxic reactions may occur • D) Since they are complex, they may be labor intensive and expensive to develop
2. Topical Administration Novel topical systems, also called transdermal drug delivery systems are patches involves percutaneous absorption
20 2.Topical Administration • Novel topical systems, also called transdermal drug delivery systems are patches involves percutaneous absorption