Eab 00 Latest Developments in Neuroscience Drug Therapy o000oc0= Melody ryan, PharmD, MPH Associate professor Departments of Pharmacy Practice Science and neurology KENTUCKY College of Pharmacy
Latest Developments in Neuroscience Drug Therapy Melody Ryan, PharmD, MPH Associate Professor Departments of Pharmacy Practice & Science and Neurology
Objectives oS. Describe new medications and/or new oE: safety concerns for the following therapeutic areas Epilepsy o000oc0= Multiple sclerosis - Stroke Alzheimer's disease KENTUCKY College of Pharmacy
Objectives • Describe new medications and/or new safety concerns for the following therapeutic areas: – Epilepsy – Multiple sclerosis – Stroke – Alzheimer’s disease
Epilepsy · New medications 00 Lacosamide Ezogabine/retigabine Clobazam o000oc0= Perampanel Brivaracetam KENTUCKY College of Pharmacy
Epilepsy • New medications – Lacosamide – Ezogabine/retigabine – Clobazam – Perampanel – Brivaracetam
Lacosamide 8· Mechanism of action 00 Enhances slow sodium channel inactivation Binds to the collapsin-response mediator protein 2(CRMP-2) o000oc0= May help prevent rearrangement of neuronal connections May protect neurons from excitotoxicity and apoptosIs KENTUCKY College of Pharmacy
Lacosamide • Mechanism of action – Enhances slow sodium channel inactivation – Binds to the collapsin-response mediator protein 2 (CRMP-2) • May help prevent rearrangement of neuronal connections • May protect neurons from excitotoxicity and apoptosis
Eab Physiology of Voltage-Gated Sodium Channels Classical AEDs Repolarization 00 Inactivated state- fast Local anesthetics Eo (within msec) Resting Depolarization Open o000oc0= g state state Inactivated state- slow (within sec and beyond) ①○×① Regulation of sodium channel long-term availability o%Adapted from Beyreuther, et al msec=milliseconds: Nat=sodium: sec=seconds LACOSAMIDE KENTUCKY CNS Drug Rev 2007; 13(1): 21-42 College of Pharmacy
LACOSAMIDE Adapted from Beyreuther, et al. CNS Drug Rev 2007;13(1):21–42. msec=milliseconds; Na+=sodium; sec=seconds Regulation of sodium channel long-term availability Local anesthetics Classical AEDs Resting state Resting membrane potential Open state Depolarization (within sec and beyond) Inactivated state-slow Repolarization Physiology of Voltage-Gated Sodium Channels Inactivated state-fast (within msec)