药物储库电池回流储库 图离子导入示意图 26
26 图 离子导入示意图
Advantages of Ip (a) Control of the delivery rates by variations of current density, pulsed voltage, drug concentration, and ionic strength (b)Eliminating gastrointestinal incompatibility erratic absorption, and first-pass metabolism (c)Reducing side effects and variation among patients (d)Avoiding the risks of infection, inflammation and fibrosis associated with continuous injection or infusion (e) Enhancing compliance with a convenient and noninvasive therapeutic regimen 27
27 Advantages of IP • (a) Control of the delivery rates by variations of current density, pulsed voltage, drug concentration, and ionic strength • (b) Eliminating gastrointestinal incompatibility, erratic absorption, and first-pass metabolism • (c) Reducing side effects and variation among patients • (d) Avoiding the risks of infection, inflammation, and fibrosis associated with continuous injection or infusion • (e) Enhancing compliance with a convenient and noninvasive therapeutic regimen
补充内容 Co& Macroflux@ technology Macroflux⑧ technology(微针技术) incorporates a titanium microprojection array affixed to a polymeric adhesive back When the patch is applied to the skin the drug-coated microprojections penetrate through the skins barrier layer into the epidermis 28
28 Macroflux® technology • Macroflux® technology（微针技术） incorporates a titanium microprojection array affixed to a polymeric adhesive back . • When the patch is applied to the skin, the drug-coated microprojections penetrate through the skin's barrier layer into the epidermis. 补充内容
Macrof|ux⑧ technology Drug is absorbed by the microcapillaries for systemic distribution The rate of absorption is promoted by the high local drug concentration around the micropro jections and the large surface area provided by the patch array 29
29 • Drug is absorbed by the microcapillaries for systemic distribution. • The rate of absorption is promoted by the high local drug concentration around the microprojections and the large surface area provided by the patch array. Macroflux® technology
Macrof|ux⑧是一种新兴的透 皮给药技术 具有长约200um的钛制微针头 携带药物微针头 可以穿透角质层 角质层(10-15m) 表皮层(50-150μm) 真皮层 30
30 Macroflux® 是一种新兴的透 皮给药技术… 具有长约 200µm的钛制微针头， 可以穿透角质层 表皮层 (50-150 µm) 真皮层 角质层 (10-15 µm) 携带药物微针头