Distribution metabolism and elimination Metabolites Drug at absorption Drug administration In bi00go3 Urine site Distribution ?Other Other fluids excretory of Issues fluids distribution
Distribution, metabolism and elimination Metabolites Drug at administration site Drug in Blood Urine Other excretory fluids Other fluids of distribution Tissues Distribution elimination absorption metabolism
Effect of metabolism on activity and toxicity Toxic metabolite toxicity Active metabolite Altered activity Drug Inactive metabolite → L oSS of activity Reversible metabolite Prolonged activity
Effect of metabolism on activity and toxicity Drug T oxic metabolite Inactive metabolite R eversible metabolite Active metabolite L oss of activity toxicity P rolonged activity Altered activity
研究项目内容 1血药浓度时间曲线 2药物的吸收 3药物的分布 4药物的排泄 5药物与血浆蛋白的结合 6药物的生物转化 7对药物代谢酶活性的影响 8药代动力学与毒代动力学
研 究 项 目 内 容 • 1 血药浓度-时间曲线 • 2 药物的吸收 • 3 药物的分布 • 4 药物的排泄 • 5 药物与血浆蛋白的结合 • 6 药物的生物转化 • 7 对药物代谢酶活性的影响 • 8 药代动力学与毒代动力学