24.3 Immunoglobulin genes are assembled from their parts in lymphocytes V Genes C Genes Family Man Mouse Man Mouse Lambda <300 2 >6 4 Kappa <300 ~1000 1 1 Heavy ~300 >1000 9 8 Table 24.1 Each immunoglobulin family consists of a cluster of V genes linked to its C gene(s). 情華大当
Table 24.1 Each immunoglobulin family consists of a cluster of V genes linked to its C gene(s). 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Family V Genes C Genes Man Mouse Man Mouse Lambda <300 2 >6 4 Kappa <300 ~1000 1 1 Heavy ~300 >1000 9 8
24.3 Immunoglobulin V gene segment C gene segment genes are assembled Leader Intron Variable Jsegmentintron Constant Germline NVVVM八MM from their parts in Codons 190-4 4to+97 98to10 110to COOH lymphocytes Somatic recombination Figure 24.5 The Lymphocyte DNA NNN入0M lambda C gene Transcription VJjunction segment is preceded Nudear RNA by a J segment,so that Splicing V-J recombination mRNA generates a functional Translation lambda light-chain Immunoglobulin light chain gene. wwww% griable Constant 清菜大兰
Figure 24.5 The lambda C gene segment is preceded by a J segment, so that V-J recombination generates a functional lambda light-chain gene. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Gem lineLeader Intron Figure 24.6 The 光米咒八总米丸八光八界入兴六 kappa C gene segment is Som atic recom bination at J2 preceded by multiple J Lym phocyte DNA八八N八八八入八NN入不 segments in the Transcription germ line.V-J V-J junction joining may Nuclear RNA J2 J3 recognize any one of the J segments, Splicing of J2 to C which is then mRNA spliced to the C Translation gene segment during RNA Imm unoglobulin light chain SSCSCOCO.OCOC processing. Variable C onstant 清菜大当
Figure 24.6 The kappa C gene segment is preceded by multiple J segments in the germ line. V-J joining may recognize any one of the J segments, which is then spliced to the C gene segment during RNA processing. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Bmn光咒亮入米米R,入汽宽Nペ天闪 Variable Constant Figure 24.7 Heavy genes D↓ are assembled NNN入入不风八，N入VZ0000202 by sequential Joining DJ junction reactions. First a D V-D joining segment is Lymphocyte DNA A风八入入NN入N八NNN闪 joined to aJ segment;then V-D jundion a V gene Actual strucure ofC gene is interupted segment is joined to the DUU0020000000 D segment. CH1 IntrorHingentron CH2 Intron CH3 清第大当
Figure 24.7 Heavy genes are assembled by sequential joining reactions. First a D segment is joined to a J segment; then a V gene segment is joined to the D segment. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.4 The diversity of germline information V,gene segments JxFA JASx2 JAFx3 2 in mouse 4 J-C gene segments in mouse ~300 in man >6 J-C gene segments in man Figure 24.8 The lambda family consists of V gene segments linked to a small number of J-C gene segments. 情菜大当
Figure 24.8 The lambda family consists of V gene segments linked to a small number of J-C gene segments. 24.4 The diversity of germline information