24.3 Immunoglobulin genes are assembled from their parts in lymphocytes V Genes C Genes Famil Man Mouse Man Mouse Lambda <300 6 4 Kappa<300~1000 Heavy 300>1000 Table 24. 1 Each immunoglobulin family consists of a cluster of v genes linked to its C gene(s) 消当
Table 24.1 Each immunoglobulin family consists of a cluster of V genes linked to its C gene(s). 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Family V Genes C Genes Man Mouse Man Mouse Lambda <300 2 >6 4 Kappa <300 ~1000 1 1 Heavy ~300 >1000 9 8
24.3 Immunoglobulin v gene segment c gene segment genes are assembled Leader inton anable J segment Intron Constant Gem line AA from their parts in Codons -19 to-4 -4to+97 98t110 1 10to cooh lymphocytes Somatic recombination Figure 24.5 The Lymphocyte DNA AA lambda c gene Transcription wJjundit segment is preceded Nudear rna by a j segment, so that Splicing V- recombination mRNA generates a functional Transation lambda light-chain Immunoglobulin light chain gene vanable Constant 消当
Figure 24.5 The lambda C gene segment is preceded by a J segment, so that V-J recombination generates a functional lambda light-chain gene. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Fe246h类人八类入久八类界 kappa C gene segment IS Som atic recom bination at J2 ↓ preceded b y multiple Lym phocyte DNA△w segments in the Transcription germ line. V-J V-J junction Joining may nuclear rna recognIze any one of the J segments Splicing of J2 to c which is then mrNA spliced to the C Translation gene segment during RNA Imm unoglobulin light chain processing. Variable Constant 请莘大
Figure 24.6 The kappa C gene segment is preceded by multiple J segments in the germ line. V-J joining may recognize any one of the J segments, which is then spliced to the C gene segment during RNA processing. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.3 Immunoglobulin genes are assembled from their parts in lymphocytes Figure 24.7 Heavy genes D-J joining ↓ are assembled y sequent Joining D junction reactions First a d V-D joint segment is Lymphocyte DNA MA joined to a J segment: then V-D jun a v gene Actual strucure of c gene is interupted segment IS Joined to the D segment IntrorHingentron CH2 Intron 消当
Figure 24.7 Heavy genes are assembled by sequential joining reactions. First a D segment is joined to a J segment; then a V gene segment is joined to the D segment. 24.3 Immunoglobulin genes are assembled from their parts in lymphocytes
24.4 The diversity of germline information v, gene segments 122是3 lIu‖‖ 2 in mouse 4 J-c gene segments in mouse 00 in man >6 J-C gene segments in man Figure 24. 8 The lambda family consists of v gene segments linked to a small number of j-c gene segments 请莘大
Figure 24.8 The lambda family consists of V gene segments linked to a small number of J-C gene segments. 24.4 The diversity of germline information