Antigenic structure a气, ■LPS Rickettsia tsutsugamushi CoXiella burnetii(Q fever LPS I Smooth LPSI roug h Weil-Felix reaction a Surface protein(SPA)
Antigenic structure LPS Rickettsia tsutsugamushi Coxiella burnetii (Q fever) LPSⅠ smooth LPSⅡ rough Weil-Felix reaction Surface protein(SPA)
Transmission a Typhus, spotted fever and trench fever are transmitted via arthropod vectors aQ fever is acquired via inhalation or ingestion of contaminated milk or food
Transmission Typhus, spotted fever and trench fever are transmitted via arthropod vectors; Q fever is acquired via inhalation or ingestion of contaminated milk or food
Pathogenesis: vasculitis Virulence factors endotoxin phospholipase A, and slime layer Sites: vascular system producing vasculitis 血管炎 Characteristic triad of symptoms fever, headache and rash(no rash with Q fever)
Pathogenesis：vasculitis Virulence factors: endotoxin, phospholipase A, and slime layer Sites: vascular system producing vasculitis 血管炎 Characteristic triad of symptoms: fever, headache and rash (no rash with Q fever)
Replication cycle of Rickettsia and Orientia ,二知 Rickettsia infection of an endothelial cell Phagocytosis is induced Lysis of cell: R prowazekii 0o→(。 Bacterium escapes from phagosome Filopodium focal lysis: R. rickettsii adding: R tsutsugamushi
Replication cycle of Rickettsia and Orientia
rickettsial family of diseases a气, a Four groups The spotted fever group The typhus group The Ehrlichia group Q fever
rickettsial family of diseases Four groups The spotted fever group The typhus group The Ehrlichia group Q fever