Disruption of neuromuscular signaling1. Occupationofacetylcholine receptorAxonMitochondriortermina---curareAcetyICoAAcetylcholine2.Inhibitionof acetylcholinesterase (AChEEnzymehSynapticvesicle---organophosphates-pesticides3. Blocking the releasing ofacetylcholine(ACholineCholinergicreceptofromAchvesiclesAcetate---botulinumtoxinPostsynapticAcetyicholinesterase(AChE)cellCurarePesticidesFoodpoison
Disruption of neuromuscular signaling 1. Occupation of acetylcholine receptor - curare 2. Inhibition of acetylcholinesterase (AChE) - organophosphates-pesticides 3. Blocking the releasing of acetylcholine (ACh) from ACh vesicles - botulinum toxin Curare Pesticides Food poison
SkeletalMuscleCellsStructure of a Skeletal MuscleMusclefibre(cell)PerimysiumBloodvesselBoneSarcoplasmicreticulumMusclefibreMyofibrilcellMyosinActinSarcomereFascicleTendonEpimysiurnEndomysium
Skeletal Muscle Cells
MyofibrilIbandAbandIbandZ discHzoneZ discMlinPart of askeletalmusclefiber(cell)SarcolemmaTriad1MitochondrionMyofibrilsMyofibrilTubules ofsarcoplasmicreticulumSarcolemmaTerminal cisternaofthesarcoplasmicreticulumTtubuleSarcoplasm.ThisisthemusclefibercytoplasmItcontainsglycosomes(granulesofglycogen)andtheoxygen-bindingproteincalledmyoglobin..Isisalmostcompletelyfilledwithcontractilefilamentscalledmyofilaments
Myofibril
SarcomereMuscleSarcomereNucleiBundleofMlineZlineZlinemusclefibersSinglemusclefiberThinfilament(cell)ThickfilamentTitinfilamentZ discZdiscMineMyofibril10000000009LightDarkZlinebandband01000ESarcomereSarcomereZoneofZoneofHzoneoverlapoverlapIbandAbandIbandIbandIbandAbandZdisc-alinethatseparatesonesarcomerefromanotherM lineaThickfilamentsM line-central lineofthesarcomerewheremyosinfilamentsareanchored(myosin)Hzone-theareawhereonlymyosinfilamentsarepresent聘Iband-theareawhereonlyactinfilamentsarepresentThinfilamentsaAband-includesoverlappingmyosinandactinfilaments(actin)ZlineZlineHzoneSarcomere
Sarcomere
SarcoplasmicReticulumSystemSarcoplasmicReticulum:Skeletal Muscleonemyofibrilmyofilaments1/2IbanoTtubuleterminalcisternaTerminalcisternaestorescalciumAbandtubules ofsarcoplasmicreticulumtriad1/2IbandSarcoplasmicReticulum.Thisisthesmoothendoplasmicreticulum(SER)inthemusclefiberItisanetworkoftubessurroundingmyofibrilsItreabsorbs calciumionsduringrelaxationItreleasescalciumionstocausecontraction
Sarcoplasmic Reticulum System Terminal cisternae stores calcium