第十四章核苷酸的代谢 ☆核苷酸是DNA和RNA的活化前提 ☆核苷酸的衍生物是许多是讷购物合成中的活化中 间产物 ☆腺嘌呤核苷酸如ATP是通用的能量货币 ☆腺嘌呤核苷酸是三大辅酶NADH,FADH及CoA 的组 ☆核苷酸是代谢调节物。 环AMP是许多激素作用的媒介 ATP起的共价修饰作用可改变酶的活性
第十四章核苷酸的代谢 ☆核苷酸是DNA和RNA的活化前提 ☆核苷酸的衍生物是许多是讷购物合成中的活化中 间产物 ☆腺嘌呤核苷酸如ATP是通用的能量货币 ☆腺嘌呤核苷酸是三大辅酶NADH，FADH及CoA 的组 ☆核苷酸是代谢调节物。 环AMP 是许多激素作用的媒介 ATP起的共价修饰作用可改变酶的活性
Key Terms ·nucleoside nucleotide pyrimidine carbamoyl phosphate synthetase(CSP) ATP-grasp fold 5-phosphoribosyl-1-pyrophosphate(PRPP) orotidylate purine 。 salvage pathway inosinate 。 hypoxanthine glutamine phosphoribosyl amidotransferase ribonucleotide reductase thymidylate synthase dihydrofolate reductase ·lll.Synthesizing
Key Terms • nucleoside nucleotide • pyrimidine • carbamoyl phosphate synthetase (CSP) • ATP-grasp fold • 5-phosphoribosyl-1-pyrophosphate (PRPP) • orotidylate • purine • salvage pathway • inosinate • hypoxanthine • glutamine phosphoribosyl amidotransferase • ribonucleotide reductase • thymidylate synthase • dihydrofolate reductase • III. Synthesizing
3 NADH FADH Key (NAD FAD)
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A C G T A 5'End 3'End P P OH
0 =0 2'3'-Cyclic CH, 0 Mixture of 2'.and monophosphate →3'-monophosphate CH. 0 Base, derivative H derivatives H OH 0-P=0 OH Base CH. 0 Base H OH =0 P=0 H OH Shortened RNA RNA