Allergic rhinitis·Pathogenesis00Mast-cellMastcellReleaseofmediators ofstimulationacuteand chronic inflammationFCeRIAllergenCUptakeof2allergenbyIgEdendriticcellsIL-4,IL-5andIL-10PrecursorExpansionofThelper cellTH2-typecellsTCR国MHCclass llProductionofIgE-DendriticcellNatureReviewslmmunology
Allergic rhinitis • Pathogenesis
Allergicrhinitis·PathogenesisThesemediatorare responsibleforsymptomatologyofallergicdiseaseDepending on the tissues involved,theremay be vasodilation,mucosaloedema,Infiltrationwitheosinophils,excessivesecretionfrom nasal gland or smoothmusclecontraction
Allergic rhinitis • Pathogenesis These mediator are responsible for symptomatology of allergic disease. Depending on the tissues involved, there may be vasodilation , mucosal oedema, Infiltration with eosinophils, excessive secretion from nasal gland or smooth muscle contraction
Allergic rhinitis·Pathogenesisit is also gets“primed"to other non-specificantigens to which patient was not exposedAllergicrespondoccurs in2phase:1.Acuteorearlyphase.2.Lateordelayedphase
Allergic rhinitis • Pathogenesis it is also gets “primed” to other non-specific antigens to which patient was not exposed. Allergic respond occurs in 2 phase: 1. Acute or early phase. 2. Late or delayed phase
AllergicrhinitisClinicalfeaturesThere are no age or sex predilection. It may startin infants as young as 6months or older peopleUsually the onset is at 12-16 years of age.The cardinal symptoms of season nasal allergyinclude paroxysmal sneezing. 10-20 sneezes ata time, nasal obstruction, watery nasaldischarge and itching in the nose
Allergic rhinitis • Clinical features There are no age or sex predilection. It may start in infants as young as 6 months or older people. Usually the onset is at 12-16 years of age. The cardinal symptoms of season nasal allergy include paroxysmal sneezing. 10-20 sneezes at a time, nasal obstruction, watery nasal discharge and itching in the nose
Allergic rhinitis·Clinicalfeatures过敏性鼻炎症状主要症状：流递、鼻塞、鼻痒、喷嚏
Allergic rhinitis • Clinical features