☆ Mechanism of action: Amino 50s acid Charged tRNA Donor Acceptor site site mRNA ① Chloramphenicol ② Macro|ides, 30s Clindamycin ③ Tetracyclines Uncharged tRNA
❖ Mechanism of action: ①Chloramphenicol ②Macrolides, Clindamycin ③Tetracyclines
Lincomycin Clindamycin Pharmacokinetics about 9o% protein-bound excretion via the liver bile, and urine penetrate well into most tissue, including bone, but not CSF
Pharmacokinetics • about 90% protein-bound • excretion via the liver,bile, and urine • penetrate well into most tissue, including bone, but not CSF. Lincomycin & Clindamycin
Lincomycin clindamycin Clinical Uses severe anaerobic infection aerobic G+ cocci infection · combination with pyrimethamine(乙胺密啶) for AIDS-related toxoplasmosis(弓形体病 combination with primaquine(伯氨鉴)for AIDS-related pneumocystis carinii pneumonia(肺囊虫性肿炎)
Clinical Uses • severe anaerobic infection • aerobic G+ cocci infection • combination with pyrimethamine (乙胺嘧啶) for AIDS-related toxoplasmosis（弓形体病） • combination with primaquine (伯氨喹) for AIDS-related pneumocystis carinii pneumonia（肺囊虫性肺炎）. Lincomycin & Clindamycin
Lincomycin clindamycin Adverse response: 1)Gl effects: Antibiotic-associated colitis(pseudomembranous colitis 伪膜性结肠炎) 2 allergic reaction 3)impaired liver function
Adverse response: 1) GI effects: Antibiotic-associated colitis (pseudomembranous colitis 伪膜性结肠炎). 2) allergic reaction 3) impaired liver function Lincomycin & Clindamycin
Vancomycins Vancomycin(万古零素) Norvancomycin(去甲万古零素) Teicoplanin(替考拉宁,太古霉亲
Vancomycin (万古霉素) Norvancomycin (去甲万古霉素) Teicoplanin (替考拉宁，太古霉素) Vancomycins