Outlines Clinical Pharmacogenetics Drug toxicity and adverse drug reactions ■Drug interactions ■Homework
Outlines Clinical Pharmacogenetics Drug toxicity and adverse drug reactions Drug interactions Homework
Clinical Pharmacogenetics
Clinical Pharmacogenetics
Case report 1 Case report 2 ● 62 y.0.man hospitalized 56 y.o.man hospitalized for pneumonia with cough for hypertension ● Treated with“standard” doses of Codeine as a “Ordinary”Metoprolol (B1 adrenergic receptor inhibitor) cough suppressant 20mg bid ● Coma Morphine levels 20X Blood pressure not expected levels decrease
Case report 1 62 y.o. man hospitalized for pneumonia with cough Treated with “standard” 56 y.o. man hospitalized for hypertension “Ordinary ” Metoprolol Case report 2 Treated with “standard” doses of Codeine as a cough suppressant Coma Morphine levels 20 × expected levels “Ordinary ” Metoprolol (β1 adrenergic receptor inhibitor) 20mg bid Blood pressure not decrease
Factors Determining Interindividual Variations in Drug Response High/Body weight Genetic factors Sex Environmental Factors Age 白 iet/Smoking Elderly Comedications Children Interindividual Neonates Variability in Drug Response Disease Process Organ function 个 Liver,Kidney,Cardiac Concomitant Disease
Factors Determining Interindividual Variations in Drug Response Sex High/Body weight Environmental Genetic factors Age Elderly Children Neonates Concomitant Disease Disease Process Organ function Liver, Kidney, Cardiac Environmental Factors Diet / Smoking / Comedications Interindividual Variability in Drug Response
This is the individual difference. And the pharmacogenetics is to explain the reason of the individual difference
This is the individual difference. And the pharmacogenetics is to explain the reason of the individual difference