Clinical Pharmacokinetics Sun Wu-Yi Institute of Clinical Pharmacology, ∥EDICAL UNIVERSTT 125 Anhui Medical University
Clinical Pharmacokinetics Sun Wu-Yi Institute of Clinical Pharmacology, Anhui Medical University
What is Pharmacokinetics (PK)? 295 PK is the description of the time course of a drug in the body,encompassing absorption,distribution, metabolism, and excretion (ADME) o What the body does to the drug? 2
What is Pharmacokinetics (PK) ? PK is the description of the time course of a drug in the body, encompassing absorption, distribution, metabolism, and excretion (ADME). 2 What the body does to the drug?
Why study Pharmacokinetics? Development and evaluation of new drugs Rational dose selection Therapeutic drug in therapeutics monitoring (TDM) e Decrease the risk of adverse effects while maximizing pharmacologic response of the medications 3
Why study Pharmacokinetics? Development and 3 Rational dose selection in therapeutics evaluation of new drugs Therapeutic drug monitoring (TDM) Decrease the risk of adverse effects while maximizing pharmacologic response of the medications
Outline ADME factors Review of Basic Pharmacokinetic Parameters Mathematical Basis of Clinical Pharmacokinetics Applications of Clinical Pharmacokinetics Factors affecting selection of the drug Clinical Pharmacokinetics in Drug Development Study questions 4
Outline ADME factors Review of Basic Pharmacokinetic Parameters Mathematical Basis of Clinical Pharmacokinetics 4 Applications of Clinical Pharmacokinetics Study questions • Factors affecting selection of the drug • Clinical Pharmacokinetics in Drug Development
ADME Factors
ADME Factors