Clinical Ouestion?Apatient inthecoronarycareunitis startedon lidocaine for treatmentofventriculararrhythmias.Ifthispatienthas severecongestiveheartfailure(EF<20%)howwouldthereguireddaily dosage oflidocaine likelybeaffected?
Clinical Question? A patient in the coronary care unit is started on lidocaine for treatment of ventricular arrhythmias. If this patient has severe congestive heart failure (EF < 20%), how would the required daily dosage of lidocaine likely be affected?
Answer to Clinical OuestionQHFpCLiCLH=QH + FpCLiQHCLH=QHCHFDecreases
Answer to Clinical Question CLH = QHFpCLi QH + FpCLi CLH = QH CHF Decreases QH
Half-LifeThe time for the concentrationof drugintheplasmato decreasebyone-half10米(00eso0Suon一*523Time(hours)
Half-Life The time for the concentration of drug in the plasma to decrease by one-half 10 5 1 * * Time (hours) 1 2 3
Steady Statemax,ssCavg, ssuonCmin,ssTime
Steady State Time Cavg, ss Cmax, ss Cmin, ss
Steady StateDuration of DrugSteady StateAdministrationConcentration(Half-Lives)Reached5023456７7587.593.7596.87598.473599.25
Steady State Duration of Drug Administration (Half-Lives) Steady State Concentration Reached 1 50 2 75 3 87.5 4 93.75 5 96.875 6 98.4735 7 99.25