Hepatic ClearanceQHFCLiCLH =QH + FpCLiQH = Hepatic blood flowFp = Fraction of free drug in plasmaCLi= Intrinsic clearance
Hepatic Clearance CLH = QHFpCLi QH + FpCLi QH = Hepatic blood flow Fp = Fraction of free drug in plasma CLi = Intrinsic clearance
Hepatic ClearanceDrugs with a high intrinsic clearanceQHFCLiQHFpCLCLH =QH+ FpCLiFpCLiQHCLH =
Hepatic Clearance CLH = QHFpCLi QH + FpCLi Drugs with a high intrinsic clearance = QHFpCL i FpCLi CLH = QH
Hepatic ClearanceDrugs with a low intrinsic clearanceQHFCLiQHFpCLCLH =QH + FpCLiDCLH = FpCLi
Hepatic Clearance CLH = QHFpCLi QH + FpCLi = QHFpCL i QH CLH = FpCLi Drugs with a low intrinsic clearance
Intrinsic ClearanceLowHigh CLiCLiwarfarinpropranolollidocainephenytointheophyllinemorphinediazepamnitroglycerin
Intrinsic Clearance High CLi Low CLi propranolol warfarin lidocaine phenytoin morphine theophylline nitroglycerin diazepam
Clinical Ouestion?Smokingis knownto increasetheenzymesresponsiblefortheophyllinemetabolism.Would a patient with ahistoryofsmokinglikely reguireahigher,lower,oreguivalenttheophyllinetotaldailydosecomparedtoa nonsmoker?
Clinical Question? Smoking is known to increase the enzymes responsible for theophylline metabolism. Would a patient with a history of smoking likely require a higher, lower, or equivalent theophylline total daily dose compared to a nonsmoker?