Comparison of meningococcus and gonococcus Signs and symptoms of two diseases Gonococcus(highly invasive) cause symptoms frequently but sites are localized Production of pus and pain during urination Sequellae depending on location Inflammation of fallopian tubes Pelvic inflammatory disease > May result in scarring leading to infertility and ectopic pregnancy BIOL 533 7 Lecture ll
BIOL 533 7 Lecture 11 Comparison of Meningococcus and Gonococcus • Signs and symptoms of two diseases – Gonococcus (highly invasive) cause symptoms frequently, but sites are localized • Production of pus and pain during urination • Sequellae depending on location – Inflammation of fallopian tubes – Pelvic inflammatory disease » May result in scarring, leading to infertility and ectopic pregnancy
Comparison of meningococcus and gonococcus Signs and symptoms Meningococcus(highly serum-resistant ) causes septicemia with multiple organ involvement, including cns Damage caused by Disseminated intravascular coagulation(DIC), accompanied by shock fever, and other responses Due to large amount of endotoxin in blood, tissues Due to ability of meningococcus to thrive in blood BIOL 533 Lecture ll
BIOL 533 8 Lecture 11 Comparison of Meningococcus and Gonococcus • Signs and symptoms – Meningococcus (highly serum-resistant )- causes septicemia with multiple organ involvement, including CNS – Damage caused by • Disseminated intravascular coagulation (DIC), accompanied by shock, fever, and other responses • Due to large amount of endotoxin in blood, tissues • Due to ability of meningococcus to thrive in blood
Neisseria meningitidis Morphology Encapulated gram diplococci e Colonization Asymptomatically in nasopharnyx of healthy ndividuals BIOL 533 Lecture ll
BIOL 533 9 Lecture 11 Neisseria meningitidis • Morphology – Encapulated Gram— diplococci • Colonization – Asymptomatically in nasopharnyx of healthy individuals
Neisseria meningitidis Microbial physiology and structure Colony morphology Form transparent, non-pigmented, non-hemolytic colonies on chocolate blood agar in 5% cO2 Capsule indicated by large mucoid colonies Physiology o Oxidase+ Acid production from glucose and maltose, but not sucrose or lactose Several serotypes known BIOL 533 Lecture ll
BIOL 533 10 Lecture 11 Neisseria meningitidis • Microbial physiology and structure – Colony morphology • Form transparent, non-pigmented, non-hemolytic colonies on chocolate blood agar in 5% CO2 – Capsule indicated by large mucoid colonies – Physiology • Oxidase+ • Acid production from glucose and maltose, but not sucrose or lactose • Several serotypes known
Neisseria meningitidis Causes of pathogenesis ability to colonize nasopharny nyx due to presence of pili ability to resist host defenses and spread due to presence of capsule Expression of toxic effects due to presence of endotol×in BIOL 533 Lecture ll
BIOL 533 11 Lecture 11 Neisseria meningitidis • Causes of pathogenesis – Ability to colonize nasopharnyx due to presence of pili – Ability to resist host defenses and spread due to presence of capsule – Expression of toxic effects due to presence of endotoxin