因酸( Nicotinic acid)、烟酰股 NAD+ CoI NADP+ Co l 又称 Vit PP,或抗糙皮病(癞皮病)维生素, 是含N杂环吡啶,体内主要以烟酰胺形式存在。 烟酰胺是Col和CoI的组成成分,(oI为烟酰胺 腺嘌呤二核苷酸 Nicotinamide Adenine Dinucleotide, NA、Co为烟酰胺腺嘌呤二核苷酸磷酸 NIcotinamide Adenine Dinucleotide Phosphate, NADP]。生物体脱氢酶类的辅酶,起携带和传递 氢的作用。 缺乏:引起癜皮病、口腔炎、舌炎、腹痛、腹 泻、痴呆、神经紊乱等
烟酸（Nicotinic Acid）、烟酰胺和 NAD+ [Co I]、NADP+ [Co II] •又称Vit PP，或抗糙皮病（癞皮病）维生素， 是含N杂环吡啶，体内主要以烟酰胺形式存在。 •烟酰胺是CoI和CoII的组成成分，CoI为烟酰胺 腺嘌呤二核苷酸[Nicotinamide Adenine Dinucleotide, NAD]、 CoII为 烟酰胺腺嘌 呤二核苷酸磷酸 [Nicotinamide Adenine Dinucleotide Phosphate, NADP]。生物体脱氢酶类的辅酶，起携带和传递 氢的作用。 •缺乏：引起癞皮病、口腔炎、舌炎、腹痛、腹 泻、痴呆、神经紊乱等
尼克酸 nicotinic aci id尼克酰胺l nicotinamide Ipyridine-3-carboxylic[3-pyridinecarboxylic ac acid amide
烟酸和烟酰胺 尼克酸[nicotinic acid] [pyridine-3-carboxylic acid] 尼克酰胺[nicotinamide] [3-pyridinecarboxylic acid amide]
NicotinIc Add Niacin、 vitamin b3、 niacinamide、 antipellagra vitamin Both form are active the free acid and the amide Sources: organ meat(largest source), fish, yeast, dried fruit, nuts, cereal grains, some vegetables Pellagra-inducing diets: corn meal, corn starch, sweet potatoe, rice, syrup, pork fat
Nicotinic Acid • Niacin、vitamin B3、niacinamide、 antipellagra vitamin. • Both form are active: the free acid and the amide. • Sources: organ meat (largest source), fish, yeast, dried fruit, nuts, cereal grains, some vegetables. • Pellagra-inducing diets: corn meal, corn starch, sweet potatoe, rice, syrup, pork fat
BiocheicalFunction NH2 NH, NAD+ NADH +H+ or NADP+ or NadPh+h+ In the older literature nad+ is referred to as DPN or coenzyme l, NADP+ is referred to as TPN or coenzymeⅢ
Biochemical Function N C N H2 O N C N H2 H H O NAD+ or NADP+ + H+ NADH + H+ or NADPH + H+ In the older literature NAD+ is referred to as DPN or coenzyme I，NADP+ is referred to as TPN or coenzyme II
▲ HH H NH NH NH2 +H 2H. N CH, O R Aside R Bside HH 0=P-OH NADH (reduced) OHOH NH2 n Adenine O—CH2O HH NAD+ (oxidized) OH OH In NAdP this hydroxyl group is esterified with phosphate. (a)
NADH和NADPH