Immune system免疫器官（Organs）免疫细胞(Cells)·免疫分子（Molecules）细胞因子（Cytokines）:secretedbyimmunecells膜蛋白分子（Membraneboundmolecules）--粘附分子（Adherencemolecules）-各种受体（Receptors）-其它表面标记（Othersurfacemarkers）其它可溶性免疫分子（Solublemolecules）antibody,complement
Immune system • 免疫器官 (Organs) • 免疫细胞 (Cells) • 免疫分子 (Molecules) 细胞因子(Cytokines): secreted by immune cells 膜蛋白分子(Membrane bound molecules) - 粘附分子 (Adherence molecules) - 各种受体(Receptors) - 其它表面标记 (Other surface markers) 其它可溶性免疫分子(Soluble molecules): antibody, complement
THYRUMTHICD4+Epi.CD3+BMPTCD8+TH2IgMIgMPlasmaProBPreBBCFUIgGPlasmaBIgGIgACD19/20RBCMOPletPMNPlasmaIgAIgEIgEBPlasma·Cytokines （IL-1~18，INF，IFN，IGFβ-1)·Membrane markers（CD28-B7，CD40-CD40LMHCI,II，cytokinereceptors·Adhesion molecules (ICAM-1LFA-1SELECTIN,and soon图1.Complements
SC ProB CFU RBC Plet PMN MØ PreB B CD8 + CD4 + TH1 TH2 IgM IgA B IgG IgM Plasma IgG B Plasma IgE Plasma IgA B Plasma IgE •Cytokines（IL-1~18，INF，IFN，IGFβ -1） •Membrane markers（CD28-B7，CD40-CD40L，MHCI,Ⅱ ，cytokine receptors •）Adhesion molecules（ICAM-1，LFA-1，SELECTIN, and so on） •Complements 图1 BM SL THYRUM Epi. CD3 PT T + CD19/20
ImmuneresponseIst phase: Antigenpresenting2nd phase: proliferation oflymphocytes3rd phase:Effecterfunction4thphase:Apoptosis ofactivatedlymphocytes
Immune r e s p o n s e 1 st phase: Antigen presenting □ 2 nd phase: proliferation of lymphocytes □ 3 rd phase: Effecter function □ 4 th phase: Apoptosis of activated lymphocytes
IL-4.56,78,9,1011.13.14,16,17LmmunerseponseAgIL-1,IL-6,TNFMOIL-10ADCCIL-4Tr1IL-12,AbIL18I-1THOIL-10/ImmunecomplexTH3THITH2IL2ActivateIFNCTL内皮细胞complementAg成骨细胞NKPMN破骨细胞成纤维细胞InflammatierCKs&mediators肥大细胞嗜酸细胞
I m m u n e rseponse Ag MØ CTL NK ADCC B IL-4，5，6，7，8，9，10，11，13，14，16，17 Ab Immune complex Activate 内皮细胞 complement 成骨细胞 破骨细胞 成纤维细胞 肥大细胞 嗜酸细胞 TH2 Ag CKs & mediators PMN Inflammation TH0 IL-1 IL-10 IL-4 IL-2 IFN IL-1，IL-6，TNF Tr1 TH3 IL-12, IL-18 IL-10 TH1
APCCD4T cellMHCIIAgTCRCD3Antigen presenting
MHCII CD4 Antigen presenting APC T cell Ag TCR