Pathology
Pathology
Histopathology of UC Begin within the rectum and extend a variable adjacent leve 25%rectum 25-50% rectum and sigmoid or descending colon One third extend adjacent to splenic flexure or involve the entire colon A few involve the terminal ileum Diffuse, continuous, superficial and not-focal inflammation Submucosa or mucosa
Histopathology of UC Begin within the rectum and extend a variable adjacent level -25% rectum -25~50% rectum and sigmoid or descending colon -One third extend adjacent to splenic flexure or involve the entire colon -A few involve the terminal ileum Diffuse, continuous, superficial and not-focal inflammation Submucosa or mucosa
Histopathology of UC Active phase of inflammation Acute inflammation cells accumulate and invade the crypts Progressive changes Degeneration or necrosis of the crypt epithelium Crypt abscesses Shallow ulcerations extending to the lamina proprius Rarely and severe changes ToXic megacolon and spontaneous perforation
Histopathology of UC Active phase of inflammation: Acute inflammation cells accumulate and invade the crypts Progressive changes: Degeneration or necrosis of the crypt epithelium Crypt abscesses Shallow ulcerations extending to the lamina proprius Rarely and severe changes: Toxic megacolon and spontaneous perforation
Histopathology of Uc Chronic changes Distorted crypt architecture of colon Transformed, disorganized, and loss of gland Loss of cupped cells Loss and disappearance of haustration, so much as straitness Thicking of the smooth muscle Malignant tumor
Histopathology of UC Chronic changes: -Distorted crypt architecture of colon Transformed, disorganized, and loss of gland -Loss of cupped cells -Loss and disappearance of haustrations, so much as straitness -Thicking of the smooth muscle -Malignant tumor
Pathology of Uc
Pathology of UC