Histopathology of CD -Involves any segiment or combination of segments from the mouth to anus Most commonly terminal ileum and right colon 120 per invo/ve exclusively the colon 15-20 per limited to the small bowe/ 50 per Both c10 per involve the stomach and duodenum and ually with more distal disease focal, discontinuous, asymmetric, transmural inflammation All layer of mucosa, submucosa, muscle, serosa
Histopathology of CD Involves any segment or combination of segments from the mouth to anus. -Most commonly terminal ileum and right colon -20 per involve exclusively the colon -15~20 per limited to the small bowel -50 per Both -<10 per involve the stomach and duodenum and usually with more distal disease focal, discontinuous, asymmetric, transmural inflammation All layer of mucosa, submucosa, muscle, serosa
Histopathology of CD Minute Linear slating normal aphthosa u/ceration islands of mucosa EXtend deep Cobblestone throughout the layers appearance of the bowe/Wa∥ Fissula. and fistula into the mesentery or organ
Histopathology of CD Minute aphthoid Linear ulceration Isolating normal islands of mucosa Cobblestone appearance Extend deep throughout the layers of the bowel wall Fissula, and fistula into the mesentery or organ
Histopathology of CD Acute and chronic inflammatory cells invades isolated or contiguous single crypts(including producing crypt abscess)with normal adjacent glands F Transmural Inflammatory changes thickening of the bowel wall and narrowing of the lumen Fibrotic changes(healing) Permanent focal stricture Non-caseating granulomas(20%)
Histopathology of CD Acute and chronic inflammatory cells invades isolated or contiguous single crypts (including producing crypt abscess) with normal adjacent glands Transmural Inflammatory changes: thickening of the bowel wall and narrowing of the lumen Fibrotic changes (healing): Permanent focal stricture Non-caseating granulomas (<20%)
Crohn∥ etis
Crohn ileitis
Clinical manifestations
Clinical manifestations