Disorders of the adrenal cortex Cushing's Syndrome and Primary Aldosteronism 凌雁 Yan Ling Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University
Disorders of the Adrenal Cortex Cushing’s Syndrome and Primary Aldosteronism Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University 凌 雁 Yan Ling
Cushings Syndrome
Cushing’s Syndrome
Definition of Cushings syndrome Cushings syndrome comprises the symptoms and signs associated with prolonged exposure to inappropriately elevated levels of free plasma glucocorticoids The use of the term glucocorticoid in the definition covers both endogenous(cortisol) and exogenous(e.g prednisolone, dexamethasone)excess
Definition of Cushing’s Syndrome • Cushing's syndrome comprises the symptoms and signs associated with prolonged exposure to inappropriately elevated levels of free plasma glucocorticoids. • The use of the term glucocorticoid in the definition covers both endogenous (cortisol) and exogenous (e.g., prednisolone, dexamethasone) excess
Cortex of the adrenal gland secretes cortisol Adrenal gland Cortex Medulla Kidney Zona glomerulosa Zona Fasciculata Adrenal Zona reticularis land Kidney Medulla
Cortex of the Adrenal Gland Secretes Cortisol Zona Glomerulosa Zona Fasciculata Zona Reticularis Medulla
Regulation of Cortisol Secretion: Feedback Loops Circadian Stress rhythm Hypothalamic Hypothalamus CRH Anterior Pituitary · Adrenal cortex ACTH pituitary Cortisol Adrena CRH: corticotropin-releasing Immune Liv ver Muscle Adipose system tissue hormone Function Gluco- Protein ACTH: Adrenocorticotropic suppressed neogenesis catabolism Lipolysis hormone
Regulation of Cortisol Secretion: Feedback Loops • Hypothalamic • Anterior Pituitary • Adrenal cortex CRH: corticotropin-releasing hormone ACTH: Adrenocorticotropic hormone