Primary structure is refers to the H.N Amino end linear sequence of AAs linked by peptide bonds to make up a peptide Each peptide has an amino terminus, 45 conventional written on left,and a Asp G carboxyl terminus on right Peptide is not ionizable but it can Arg form hydrogen bond Pro 0 Cys Leu H3N* Asp A船 2 eas-C Carboxyl end Education.nc.publishing as Benjamin Cummings
Primary structure is refers to the linear sequence of AAs linked by peptide bonds to make up a peptide Each peptide has an amino terminus, conventional written on left, and a carboxyl terminus on right Peptide is not ionizable but it can form hydrogen bond
OH Peptide Peptide Bonds join amino acids bond OH SH It's a condensation reaction CH2 CH2 CH2 (H20 is released when the H bond is formed). N-C-C- OH H-N-C Two amino acids form a (a) DI-PEPTIDE H20 OH POLYPEPTIDES Side OH SH chains are formed from more Peptide CH2 CH2 bond than two amino acids CH2 bonded together H H Back- H-N-C-C- OH H O bone Amino end Carboxyl end (N-terminus) (C-terminus) (b) CopyrightPearson Education.Inc..publishing as Benjamin Cummings
Peptide Bonds join amino acids It’s a condensation reaction (H20 is released when the bond is formed). Two amino acids form a DI-PEPTIDE POLYPEPTIDES are formed from more than two amino acids bonded together
Proteins are linear polymers of amino acids R 2 NHs*-C-COO +NH3+-C-CO0+" H H H20 H20 R: NH3+-CtCO-NH CtCO-NH C-CO H Peptide H Peptide H A carboxylic acid bond bond condenses with an amino group with the release of a .@0 water
Proteins are linear polymers of amino acids R1 NH3 ＋ C CO H R2 NH C CO H R3 NH C CO H R2 NH3 ＋ C COOー H ＋ R1 NH3 ＋ C COOー H ＋ H2O H2O Peptide bond Peptide bond A A F G N G S T S D K A carboxylic acid condenses with an amino group with the release of a water
amino acid amino acid peptide water H 888 0 amino carboxylic amino peptide group acid group bond group Figure 3-20 Biology:Life on Earth,8/e 2008 Pearson Prentice Hall,Inc
Structure of the Peptide Bond ·The peptide bonds be less reactive,quite rigid and nearly planar Have 4 substituents:a hydrogen,an oxygen and 2a-carbon Often conventionally written as a single bonds, can not freely rotate. Polypeptide backbone is the repeating sequence of the N-C-C-N-C-C...in the peptide bond
Structure of the Peptide Bond • The peptide bonds – be less reactive, quite rigid and nearly planar – Have 4 substituents: a hydrogen, an oxygen and 2a-carbon • Often conventionally written as a single bonds, can not freely rotate. • Polypeptide backbone is the repeating sequence of the N-C-C-N-C-C… in the peptide bond